ClinicopathologÝcal Features and Survival Outcomes of 70 Tongue Squamous Cell Carcinoma Patients

INTRODUCTION: In this article, it is aimed to present the clinicopathological and demographic characteristics, treatment regimens and survival characteristics of locally advanced tongue squamous cell cancers (TSCC).
METHODS: This retrospective study included patients with histologically confirmed locally advanced TSCC followed up at the medical oncology clinic between January 2005 and June 2020. Clinicopathological features and treatment modalities of the patients were recorded from the hospital's patient registry database. The obtained data were compared statistically
RESULTS: A total of 70 patients, 42 male and 28 female, were included in the study. The 5-year OS was found to be 59%. The median disease free survival (DFS) was 4.1 years. OS could not reach the median in the 2/3 anterior tumors of the tongue, while the median OS was 6.9 years in the 1/3 posterior tumors of the tongue (p=0.046). There was no statistically significant difference between age groups in terms of median OS and median DFS. But there was a remarkable point. The median DFS was numerically shorter in patients aged 45 years and younger than in patients over 45 years of age (2 years vs. 4.5 years). Also important here was that both the median OS and the median DFS were numerically worse in women (respectively, median OS: 4.1 years vs. not reached, p=0.075; median DFS: 2.2 years vs. 5.9 years, p=0.349).
DISCUSSION AND CONCLUSION: There are few studies that examine TSCC as a separate title under these headings of oral cavity cancers and oropharyngeal cancers. In this sense, this study will contribute to the literature.

Yetmiþ Dil Skuamöz Hücre Karsinomu Hastasýnýn Klinikopatolojik Özellikleri ve Sað Kalým Sonuçlarý

GÝRÝÞ ve AMAÇ: Bu yazýda, lokal ileri dil skuamöz hücreli kanserlerin (DSCC) klinikopatolojik ve demografik özellikleri, tedavi rejimleri ve saðkalým özelliklerinin sunulmasý amaçlanmaktadýr.
YÖNTEM ve GEREÇLER: Bu retrospektif çalýþma, Ocak 2005 ile Haziran 2020 arasýnda medikal onkoloji kliniðinde takip edilen, patolojik olarak doðrulanmýþ lokal ileri DSCC'li hastalarý içermektedir. Hastalarýn klinikopatolojik özellikleri ve tedavi yöntemleri hastanenin hasta kayýt veritabanýndan kaydedilmiþtir. Elde edilen veriler istatistiksel olarak karþýlaþtýrýlmýþtýr.
BULGULAR: Çalýþmaya 42 erkek ve 28 kadýn olmak üzere toplam 70 hasta dahil edildi. 5 yýllýk gene sað kalým (OS) %59 olarak bulundu. Medyan hastalýksýz sað kalým (DFS) 4.1 yýldý. Dil ön 2/3 tümörlerinde OS medyana ulaþamadý, dilin 1/3 arka tümörlerinde medyan OS 6.9 yýldý (p=0.046). Medyan OS ve medyan DFS açýsýndan yaþ gruplarý arasýnda istatistiksel anlamlý fark yoktu. Ancak dikkat çekici nokta, medyan DFS 45 yaþ ve altýndaki hastalarda, 45 yaþýn üzerindeki hastalardan (2 yýla karþý 4,5 yýl) sayýsal olarak daha kýsaydý. Ayrýca hem medyan OS hem de medyan DFS kadýnlarda numerik olarak daha kýsaydý(sýrasýyla, medyan OS: 4,1 yýla karþý 'ulaþýlamadý', p=0,075; medyan DFS: 2,2 yýla karþý 5,9 yýl, p=0,349).
TARTIÞMA ve SONUÇ: Oral kavite kanserleri ve orofaringeal kanserler baþlýklarý altýnda DSCC'yi ayrý bir baþlýk olarak inceleyen az sayýda çalýþma bulunmaktadýr. Bu anlamda bu çalýþma literatüre katký saðlayacaktýr.