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What Is The Accuracy Of Frozen Section For Risk Triage In Endometrial Cancer?
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Original Article
VOLUME: 49 ISSUE: 2
P: 80-85
2016

What Is The Accuracy Of Frozen Section For Risk Triage In Endometrial Cancer?

Acta Haematol Oncol Turc 2016;49(2):80-85
DOI: 10.5505/aot.2016.58672
Kadir Çetinkaya
Fisun Ardıç
Funda Atalay
Ahmet Bacınoğlu
Haluk Dervişoğlu
1. Department of Obstetrics and Gynecology, Ankara Oncology Education and Research Hospital, Ankara, Turkey
2. Department of Pathology, Ankara Oncology Education and Research Hospital, Ankara, Turkey
3.
No information available.
No information available
Received Date: 2016-02-14T21:39:27
Accepted Date: 2016-06-02T10:47:00
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Abstract

INTRODUCTION

Although the current standard surgical procedure is still staging comprehensively in endometrial cancer (EC), the therapeutic effect of lymph node dissection (LND) is debatable for early stages. Therefore, it is important to identify high risk patients. In this study, it is intended to see the accuracy rate of frozen section (FS) in our institution by determining high-risk patients for lymph node metastasis (LNM) in EC.

METHODS

Intraoperative FS were studied in 37 EC patients, histopathological typing, grade, tumor size (TS), myometrial invasion depth (MID) and lymphovascular emboli (LVE) parameters were measured. These parameters were monitored and compared with the final paraffin results (PR).

RESULTS

In FS examination, the histopathological diagnosis of a patient with type I was a type II in PR (2.7%). In MID assessment one patient was (2.7%) misdiagnosed. In TS measurement, FS and PR were consistent in all patients. Referring to LVE, 4 patients (10.8%) were false negative by FS examination. FS received a false negative diagnosis in 5 patients (13.5%) for nuclear high grade and in 3 patients (8.1%) for structural high grade. The accuracy of the test sequence were calculated for histopathological type determination, MID, LVE, nuclear and structural grade as 94%, 97%, 89%, 86% and 91%, respectively. When all parameters were evaluated together, in terms of capturing the high-risk EC patients for LNM by FS examination, the sensitivity, specificity, and accuracy were calculated as 96% 100% and 97%, respectively. FS examination was failed for diagnosing one high-risk (1/37) EC patient (2.7%).

DISCUSSION AND CONCLUSION

FS examination was successful for histopathological type determination, TS and evaluation of MID but low accuracy rate was observed for LVE, for the determination of nuclear and structural grades.