EN | TR
E-ISSN: 3061-9947
The Expression of HBME1, PAX8, CD56 and CITED1 in Benign Lesions, Benign and Malignant Tumors of Thyroid
PDF
Cite
Share
Request
Original Article
VOLUME: 54 ISSUE: 2
P: 141-151
2021

The Expression of HBME1, PAX8, CD56 and CITED1 in Benign Lesions, Benign and Malignant Tumors of Thyroid

Acta Haematol Oncol Turc 2021;54(2):141-151
DOI: 10.5505/aot.2021.26818
Gamze Erkılınç 1
Sezer Kulaçoğlu 2
1. Department of Pathology University of Süleyman Demirel, Isparta
2. Ankara Bilkent City Hospital, Department of Pathology, Ankara
3.
No information available.
No information available
Received Date: 2020-04-21T22:40:25
Accepted Date: 2021-08-11T08:30:35
PDF
Cite
Share
Request

Abstract

INTRODUCTION

To evaluate the role of HBME1, PAX8, CD56 and CITED1 in distunguishing benign lesions of the thyroid from malignant tumors and different malignant tumors of the thyroid.

METHODS

The patients that underwent thyroidectomy between 2007 and 2013 were included to the study. Patients with Nodular Hyperplasia: 22, Folicular Adenoma: 14, Noninvasive Folicular Thyroid Neoplasm With Papillary-Like Nuclear Features: 3, Well Diferentiated Carcinoma, Not Otherwise Specified: 3, Papillary Carcinoma: 22, Papillary Carcinoma Folicular Variant: 12, Minimally Invasive Folicular Carcinoma: 9, Poorly Diferentiated Carcinoma: 4, Anaplastic Carcinoma: 3 were included to the study. HBME1, CITED1, PAX8, CD56 were applied by immunohistochemical method. In statistical analysis, the sensitivity, specificity, positive predictive and negative predictive values of markers were calculated.

RESULTS

CD56 (loss of expression), HBME1 was significantly higher in Papillary Carcinoma, Papillary Carcinoma Folicular Variant compared to other malignant neoplasms. The most sensitive markers for malignant tumors were PAX8 and CITED1 (90%, 88% ). The most specific markers for malignant tumors were HBME1, CITED1 (97%, 92% ). The most sensitive and specific marker for Papillary Carcinoma, Papillary Carcinoma Folicular Variant was HBME1 (100%, 80%). CD56 (loss of expression), CITED1 was the most sensitive markers for Papillary Carcinoma Folicular Variant ( 86%,86%).

DISCUSSION AND CONCLUSION

HBME1 was found an both sensititive and specific marker for Papillary Carcinoma. The cytoplasmic expression of CITED1 was significantly higher in PC compared to other malignant tumors. Nuclear expression of PAX8 was found significantly higher in benign cases compared to malignant tumors. HBME1,CD56 (loss of expression) was found significantly higher in Papillary Carcinoma, Papillary Carcinoma Folicular Variant compared to other malignant tumors.