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The Effects of Radical Nephrectomy and Nephron Sparing Surgery on Glomerular Filtration Rate for the Patients who Underwent Surgery for Localized Renal Mass
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Original Article
VOLUME: 49 ISSUE: 3
P: 164-169
2016

The Effects of Radical Nephrectomy and Nephron Sparing Surgery on Glomerular Filtration Rate for the Patients who Underwent Surgery for Localized Renal Mass

Acta Haematol Oncol Turc 2016;49(3):164-169
DOI: 10.5505/aot.2016.93063
Ahmet Güdeloğlu
Bülent Akdoğan
Haluk Özen
1. Memorial Ankara Hospital, Ankara, Turkey
2. Hacettepe University School of Medicine Department of Urology, Ankara, Turkey
3.
No information available.
No information available
Received Date: 2016-10-17T20:44:25
Accepted Date: 2016-12-14T14:15:44
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Abstract

INTRODUCTION

The goal of this study was to demonstrate the long-term effects of radical nephrectomy (RN) and nephron sparing surgery (NSS) on kidney functions.

METHODS

The medical records of 1016 patients who underwent kidney surgery from January 1990 to April 2011 at Hacettepe University School of Medicine, Department of Urology were retrospectively collected and analyzed. Metastatic 78 patients at presentation were excluded.

RESULTS

Radical nephrectomy and nephron sparing surgery was performed in 624 and 314 cases, respectively. Male to female ratio was 579/314. The mean follow up was 46.7 and 39.9 months for RN and NSS, respectively. The mean radiological tumor size was 75±33,5 mm for RN and 37,8±26 mm for NSS (p<0.001). The mean duration of surgery for RN and NSS was 137 and 139 minutes, respectively. The mean warm ischemia time for NSS was 18.9 minutes. Serum creatinin level was increased 0.51mg/dl and 0.39mg/dl for RN and NSS after long-term follow up, respectively (p<0.001). Glomerular filtration rate (GFR) was ≥ 60 ml/min/m2 in 47.6% and 74.8% of RN and NSS patients in long-term follow up, respectively (p<0.001).

DISCUSSION AND CONCLUSION

Decrease in GFR was more prominent in RN compared to NSS patients in long term. Therefore, removing the whole kidney for especially T1 renal tumours is over treatment in most cases. Partial nephrectomy should be preferred for all T1 renal tumours whenever technically feasible.