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The Effects Of Bevacizumab Treatment On Thyroid Gland And Pancreas
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Original Article
VOLUME: 53 ISSUE: 2
P: 263-266
2020

The Effects Of Bevacizumab Treatment On Thyroid Gland And Pancreas

Acta Haematol Oncol Turc 2020;53(2):263-266
DOI: 10.5505/aot.2020.56933
Özlem Demircioğlu 1
Fatma Buğdaycı Başal 2
1. Marmara University Pendik Education and Research Hospital, Department of Radiology, Istanbul, Turkey.
2. S.B.Ü. Dr. Abdurrahman Yurtaslan Ankara Oncology Education and Research Hospital, Medical Oncology, Ankara, Turkey.
3.
No information available.
No information available
Received Date: 2020-05-19T11:52:34
Accepted Date: 2020-09-04T10:56:32
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Abstract

INTRODUCTION

Bevacizumab is a vascular endothelial growth factor receptor used in cancer treatment that inhibits angiogenesis. Due to this effect, it has been shown in some experimental studies that the thyroid and pancreas sizes are reduced. Accordingly, the effects of Bevacizumab treatment on thyroid and pancreatic dimensions and functions were investigated in this study.

METHODS

Thorax and abdominal tomography taken from 50 patients with malignancy for staging and follow-up were evaluated retrospectively and thyroid right and left lobe AP diameters and pancreatic head, trunk and tail AP diameters were measured before treatment and at the 6th month of treatment. In addition, blood amylase, lipase values and thyroid function tests were evaluated from patients' tests on the system and compared in the same time frames.

RESULTS

Although a slight decrease in average values was observed with Bevacizumab treatment in all measurement values, there was no statistically significant difference. Again, in the examination studies, only 1 patient showed an increase in blood lipase value and 3 patients have a deterioration in thyroid function tests in the 6th month of treatment and there was no significant difference.

DISCUSSION AND CONCLUSION

It has been observed that bevacizumab use does not significantly change thyroid and pancreatic size and functions. However, even though there is no significant difference, it is thought that detailed prospective studies with more patient groups may be required due to the decrease in the measurements.