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The effect of surgery and radiotherapy on oncological outcomes in high-risk prostate cancer
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Original Article
VOLUME: 50 ISSUE: 1
P: 17-23
2017

The effect of surgery and radiotherapy on oncological outcomes in high-risk prostate cancer

Acta Haematol Oncol Turc 2017;50(1):17-23
DOI: 10.5505/aot.2017.52714
Taha Numan Yıkılmaz
Erdem Öztürk
İsmail Selvi
Halil Başar
1. Department of Urology, Ankara Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital,
2.
No information available.
No information available
Received Date: 2017-02-27T13:41:51
Accepted Date: 2017-04-05T15:06:18
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Abstract

INTRODUCTION

The best treatment approach is still a matter of debate in high-risk prostate cancer patients. Recommended treatment approaches are surgery (radical retropubic prostatectomy) or radiotherapy (RT) + androgendeprivationtherapy (ADT). In our study, we compared the oncological outcomes of surgery and radiotherapy in high-risk prostate cancer.

METHODS

Fifty patients who were treated with high-risk prostate cancer in our clinic were retrospectively studied between January 2008 and June 2015. Twenty patients with open radical retropubic prostatectomy (RRP) were included in the surgical group and 30 patients with RT + ADT therapy were included in the radiotherapy group. Groups were evaluated in terms of biochemical recurrence (BCN), biochemical recurrence-free survival (BFSR), cancer-specific survival (CFS), and overall survival (GFS).

RESULTS

Mean age of the patients was calculated 65.9 (range 51-83), mean baseline PSA levels were 24.2 (range 1-94.9), and mean follow-up was 50.24 months (range 6-84). The follow-up period was 55.7 months in the surgical group and 46.6 months in the RT group. Patient age, initial PSA level and clinical stage were found higher in RT group but no significant statistical difference was found. According to biopsy and prostatectomy pathologies in the surgical group; 4 (20%) patients were upgrading and 10 (50%) patients were downstaging. Four patients (20%) which observed Gleason pattern 5 was detected biochemical recurrence. No pattern 5 was detected in the biopsy of any patient in the radiotherapy group.

DISCUSSION AND CONCLUSION

Similar to many studies in the literature, we found that patients treated with RT + ADT in high risk prostate cancer had beter oncologic outcomes than those with RRP.