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The assessment of bone marrow infiltration with 18FDG-PET in non-haematopoietic solid tumors
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Original Article
VOLUME: 50 ISSUE: 2
P: 99-103
2017

The assessment of bone marrow infiltration with 18FDG-PET in non-haematopoietic solid tumors

Acta Haematol Oncol Turc 2017;50(2):99-103
DOI: 10.5505/aot.2017.92486
Ayşe Ocak Duran
Mevlude Inanc
Oktay Bozkurt
Ersin Ozaslan
Mahmut Uçar
Metin Ozkan
1. Erciyes University, Medical Faculty, Medical Oncology Department
2.
No information available.
No information available
Received Date: 2016-12-25T23:50:40
Accepted Date: 2017-08-28T12:07:14
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Abstract

INTRODUCTION

We aimed to investigate the diagnostic value of positron emission computed tomography using 18F-Fluorodeoxyglucose (18FDG-PET/CT) in bone marrow metastasis (BMM) due to solid tumors in patients who undervent bone marrow biopsy (BMB).

METHODS

53 patients who suspected BMM from solid tumors and underwent both 18FDG-PET/CT scans and BMB were evaluated retrospectively. We also looked at the predictive value of the maximum standardized uptake value (SUVmax) to detection of metastases from solid tumors.

RESULTS

Among 53 patients, BMM was detected in 36 patients via 18FDG-PET/CT and 33 patients via BMB. In 9/53 cases (16,9%) both techniques showed no BMM. In 25/53 cases (47.2%) both techniques unclosed BMM. Among these 36 18FDG-PET/CT (+) patients, 25 patients had BMM accoding to the BMB (false positive, 11/36 patients, 30,5%). Among 17/53 18FDG-PET/CT (-) patients, 8 patients had BMM according to the BMB (false negative, 8/17 patients, 47.5%). SUVmax in patients with BMM was significantly higher than in patients without BMM according to the BMB [7.1 (2.5-22.2) vs 3.3 (2.2 – 16.0, p = 0.79), p=0.024].

DISCUSSION AND CONCLUSION

These preliminary results suggest that 18FDG-PET/CT could not be superior to BMB for bone marrow assessment. However, SUVmax value should be considered for the assessment of BMM.