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Synovial Sarcoma in Pediatric Age Group: Single Center Experience
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Original Article
VOLUME: 52 ISSUE: 1
P: 25-30
2019

Synovial Sarcoma in Pediatric Age Group: Single Center Experience

Acta Haematol Oncol Turc 2019;52(1):25-30
DOI: 10.5505/aot.2019.70783
Turan Bayhan 1
Neriman Sarı 1
Ebru Atasever Akkaş 2
İnci Ergürhan İlhan 1
1. Ankara Oncology Traning and Research Hospital, Pediatric Hematology and Oncology Department, Ankara
2. Ankara Oncology Traning and Research Hospital, Radiation Oncology Department, Ankara
3.
No information available.
No information available
Received Date: 2018-09-07T00:16:11
Accepted Date: 2019-04-09T13:28:57
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Abstract

INTRODUCTION

Synovial sarcoma (SS) is generally observed in adults, however it is the most common non-rhabdomyosarcoma soft tissue sarcoma during childhood. In our study we reviewed pediatric patients with SS followed in our clinic retrospectively.

METHODS

Patients with SS diagnosed between 1993 and 2017 in Ankara Oncology Training and Research Hospital included into the study. Their files were reviewed retrospectively, clinical presentation, treatments and response of patients to treatment were investigated.

RESULTS

We analyzed data of 15 pediatric patients. Median age of patients was 14.5 (13 – 17) years, in 14 patients tumor was located in extremities. When we grouped patients based on IRS staging; five patients (33.3%) were in group I, eight patients (53.3%) were in group II, and two patients (13.3%) were in group III. Four (33%) of the 12 patients that in first remission relapse occurred; in three patients there was isolated lung relapse and in one patient relapse was from lung and external iliac lymph node. Patients were followed median 28 (5 – 85) months, three years event free survival was 53.6%, and overall survival was 73%. When we compared three years overall survival of patients based on IRS staging; 75% in IRS group I; 100 % in IRS group II; and 0% in IRS group III (p; <0.001).

DISCUSSION AND CONCLUSION

Prognosis of synovial sarcoma during childhood is very bad if surgery is not performed. In patients with remission lung is the most common region for relapse, and patients should be followed carefully for relapse if unspecified small pulmonary nodules are detected. Multi centric studies with more patients should be performed to get more valid information about our country.