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Role of RDW and MPV in Diagnosis of Colorectal Polyps and Carcinoma: A Case-Control Study
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Original Article
VOLUME: 48 ISSUE: 1
P: 1-7
2015

Role of RDW and MPV in Diagnosis of Colorectal Polyps and Carcinoma: A Case-Control Study

Acta Haematol Oncol Turc 2015;48(1):1-7
DOI: 10.5505/aot.2015.96268
Mustafa Cengiz
Abdurrahman Şahin
Kamil Özdil
Hacı Mehmet Sökmen
1. Dr. A. Y. Ankara Oncology Training And Research Hospital Department Of Gastroenterology, Ankara, Turkey
2. Fırat University Faculty Of Medicine Department Of Gastroenterology, Elazıg, Turkey
3. Umraniye Training And Research Hospital Department Of Gastroenterology, Istanbul, Turkey
4.
No information available.
No information available
Received Date: 2015-04-28T20:25:48
Accepted Date: 2015-06-18T10:07:23
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Abstract

INTRODUCTION

Mean platelet volume (MPV) and red blood cell distribution width (RDW) are simple tests in routine complete blood count. We aimed to evaluate RDW and MPV values of patients with colorectal carcinoma (CRC) and adenomas and controls.

METHODS

The MPV and RDW values of participitants who undergone colonoscopic examination for CRC screening or irritable bowel syndrome related symptoms were evaluated retrospectively. Patients were divided into three groups according to colonoscopic and histopathologic findings: CRC group, adenoma group and control group. Patients with adenomas then were separated into two subgroups according to dysplasia and villous component as high probable precancerous (HPP) and low probable precancerous (LPP) groups.

RESULTS

A total of consecutive 602 participants were enrolled into the study. There were n=130 patients in CRC, n=241 patients adenoma group and n=233 in control group. The CRC group had lower hemoglobin, MCV values and higher platelet count compared with adenoma group and control group. The median MPV values of CRC group (7.51) were lower than of adenoma group (7.91) and control group (7.90) (P<0.001, for both). The median RDW value of CRC group (15.7) was significantly higher than of adenoma group (14.6) and controls (14.4) (P=0.01, for both). When compared adenoma subgroups, the only different parameter was RDW between LPP and HPP (14.4 vs. 14.8, P=0.02). The MPV values did not differ between groups (7.89 vs. 8.04, P>0.05).

DISCUSSION AND CONCLUSION

The RDW and MPV values should be taken into consideration in patients who undergone colonoscopic screening.