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Retrospective Analysis of Demographic and Laboratory Data of Patients with Hepatocellular Carcinoma: Single Center Experience
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Original Article
VOLUME: 52 ISSUE: 1
P: 64-72
2019

Retrospective Analysis of Demographic and Laboratory Data of Patients with Hepatocellular Carcinoma: Single Center Experience

Acta Haematol Oncol Turc 2019;52(1):64-72
DOI: 10.5505/aot.2019.69672
Murat Bardakçı 1
Yakup Ergün 2
Kendal Yalçın 3
1. Diyarbakır Silvan Dr. Yusuf Azizoğlu State Hospital, Clinical Of Internal Medicine
2. Ankara Numune Training and Research Hospital, Department of Medical Oncology
3. Dicle University Faculty of Medicine, Department of Gastroenterology, Diyarbakır
4.
No information available.
No information available
Received Date: 2018-07-01T18:54:47
Accepted Date: 2019-04-09T13:34:20
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Abstract

INTRODUCTION

Hepatocellular carcinoma (HCC) is an aggressive tumor that frequently occurs in the setting of chronic liver disease and cirrhosis. In this study, we aim to evaluate the etiologic factors associated with Hepatocellular carcinoma and their role on the clinical outcome and prognosis of the disease.

METHODS

A total of 377 patients were included in the study. Patient files were retrospectively analyzed. HCC was diagnosed based on radiologic, histologic, clinical and laboratory findings. Patients were grouped according to etiology.

RESULTS

The mean age of the patients was 58.70±2.50 years and 82.2% of them were male. The vast majority of the patients were living in the city center, and 67.6% of them had primary education or lower education level. It was seen that HCC developed in cirrhosis base in 87% of the patients. When we looked at the etiologic factors, 57.8% of the patients were found to develop due to HBV, 15.6% to HDV, 8.2% to HCV and 18.3% to non-viral causes. The mean duration of infection was 9.38±9.08 years and 23.6% were taking antiviral treatment in patients with HSC due to viral etiology.

DISCUSSION AND CONCLUSION

Viral hepatitis is the most important risk factor for the development of HCC, and HCC often develops on the basis of cirrhosis. Therefore, the follow up and treatment of patients with chronic viral hepatitis and cirrhosis is of great importance. Patients with HCC in our region with low rates of anti-viral treatment and high Child-Pugh score suggest that this is still a serious health problem that is still important. Increased awareness of viral hepatitis is evident when the incidence of HCC is reduced by vaccination programs, and patients with cirrhosis will be diagnosed with HCC at an earlier stage with regular follow-up programs and will have a long-term survival benefit with more effective treatment options.