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Renal functional changes after radical cystectomy in the early-mid term period
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Original Article
VOLUME: 53 ISSUE: 3
P: 463-468
2020

Renal functional changes after radical cystectomy in the early-mid term period

Acta Haematol Oncol Turc 2020;53(3):463-468
DOI: 10.5505/aot.2020.13285
Mehmet Salih Boğa 1
Mahmut Ekrem İslamoğlu 1
Selim Taş 1
Ali Erhan Eren 1
Kamil Sarac 1
Eren Erdi Aksaray 1
Mutlu Ateş 1
1. University of Health Sciences, Antalya Training and Research Hospital, Department of Urology, Antalya
2.
No information available.
No information available
Received Date: 2020-11-28T02:30:03
Accepted Date: 2020-12-30T17:38:46
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Abstract

INTRODUCTION

To evaluate the postoperative early-mid term renal functions of patients who underwent open radical cystectomy for bladder tumor.

METHODS

In the study, demographic, operative, postoperative data and postoperative 1st day, 1st, 3rd, 6th, 9th and 12th month renal function values of 76 patients who underwent open radical cystectomy due to bladder tumor between December 2010 and October 2019 were evaluated. Patients who underwent concomitant nephrectomy, history of dialysis due to preoperative chronic renal failure, history of solitary kidney and had a follow-up less than 1 year were excluded from the study.

RESULTS

A total of 51 patients were included in the study. The mean age of the patients was 64.31 ± 8.37years. Ileal conduit was applied to 86.3% of the patients, while orthotopic bladder was applied to 13.7%. While postoperative renal functions decreased in 51% of the patients, it was found that there was an increase or no change in 49% of the patients. While preoperative eGFR was 62.70 ± 23.22 mL / min / 1.73 m2, postoperative 1-3 days, 1st month, 3rd month, 6th month, 9th month, and 12th month eGFR values were 58.55 ± 28.08, 64.67 ± 26.52, 64.35 ± 23.23, 61.18 ± 24.80, 59.93 ± 21.99 and 58.09 ± 22.33 mL / min / 1.73 m2, respectively. While the eGFR levels relatively rapid decrease in the early perioperative period, but a gradual change was observed afterward for the periodic eGFR measurements performed within 1 year after the procedure.

DISCUSSION AND CONCLUSION

The rapid deterioration in renal functions can be observed in the early period in muscle-invasive or high-risk bladder tumors after the open radical cystectomy, but it seems to approach normal values with close follow-up. In this procedure with high morbidity and mortality, we recommend close follow-up and care, especially in the early postoperative period, in order to protect renal functions.