EN | TR
E-ISSN: 3061-9947
Prognostic Value of Lymphovascular and Perineural Invasion in Colon Cancer
PDF
Cite
Share
Request
Original Article
VOLUME: 54 ISSUE: 2
P: 166-174
2021

Prognostic Value of Lymphovascular and Perineural Invasion in Colon Cancer

Acta Haematol Oncol Turc 2021;54(2):166-174
DOI: 10.5505/aot.2021.23540
Cemil Yüksel 1
Serdar Çulcu 2
Afig Gojayev 2
Salim Demirci 2
Ali Ekrem Ünal 2
1. SBU Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Surgical Oncology Department
2. Ankara University School of Medicine
3.
No information available.
No information available
Received Date: 2021-01-28T15:43:04
Accepted Date: 2021-08-11T08:33:16
PDF
Cite
Share
Request

Abstract

INTRODUCTION

Colon cancer is one of the most common types of malignant tumours in the world. Colon cancer ranks fourth among cancer-related deaths. Lymphovascular invasion (LVI) is the tumour involvement of small lymphatic or blood (typically venous) vessels while perineural invasion (PNI) is the growth of the tumour in, around, and along the nerves and nerve sheaths. In our study, we investigated the effects of LVI and PNI on prognosis, tumour stages, and lymph node metastasis in colon cancer patients.

METHODS

The data of patients, who underwent colon cancer surgery in the period between February 2013 and January 2020, were analyzed retrospectively. The surgery and pathology reports, demographic characteristics, and overall survival of the patients were examined.

RESULTS

A total of 248 patients were operated due to colon cancer. LVI and PNI were present in 120 (48.3%) and 105 (41.9%) patients, respectively. The relationship of the grade, of the presence of positive lymph nodes, LVI, and PNI, and of the T- and N-stages with the survival were statistically significant with the following p-values of 0.028, <0.001, <0.001, <0.001, 0.005, and <0.001, respectively. When the relationship of LVI and PNI with other factors was examined, it was shown that there was a statistically significant relationship in both groups in terms of T and N stage, metastatic lymph node and survival time. (p <0.001)

DISCUSSION AND CONCLUSION

Because the presence of LVI and PNI is a determinant of prognosis and lymph node metastasis especially in early-stage patients; we think that close follow-up of patients with LVI and PNI and the evaluation of such patients by a multidisciplinary council for the administration of adjuvant therapy, may affect prognosis favourably.