Abstract

INTRODUCTION

The present study aimed to investigate the potential of ratio of aspartate aminotransaminase to alanine aminotransaminase (De-Ritis ratio) as prognostic marker in adelocesant and young adults(AYAs) patients with breast cancer.

METHODS

This study retrospectively evaluated patients aged 18-39 who were followed-up from January 2006 to May 2016 at the Medical Oncology Clinic of Izmir Katip Celebi University, Ataturk Training and Research Hospital. In order to find out De-Ritis ratio cut-off values, ROC curve analysis was used. The patients were divided into two groups according to the cutoff value.

RESULTS

We had 190 patients with breast cancer in total. The median age at diagnosis was 34 (min: 23, max: 39). 37 patients (19.5%) experienced a relapse in the follow-up period. Histologically, the great majority of patients were grade 2 and 3. The univariate analysis demonstrated that De-Ritis ratio, histological grade, ER status, PR status and Luminal status were good prognostic factors in terms of disease free survival(DFS) [p: 0.014, p: 0.006, p: 0.032, p: 0.002, p: 0.05 respectively]. The group De-Ritis ratio<0,93 had 106.2 months of DFS while the group De-ritis ratio≥0,93 had 79.2 months [p<0.014]. In multivariate analysis for DFS histological grade, PR status and De-Ritis ratio were found to be statistical significance.

DISCUSSION AND CONCLUSION

In this study, it has been shown that the De-Ritis ratio can be used as a prognostic marker in AYAs with breast cancer.