Abstract

INTRODUCTION

It has been found that fibrinogen-to-albumin ratio (FAR) is closely correlated with prognosis in some cancers. But prognostic importance of FAR in small cell lung cancer (SCLC) isn’t known completely. We aimed to show the prognostic importance of FAR in SCLC in this study.

METHODS

145 patients followed up with diagnosis of SCLC were included in the study retrospectively. According to the receiver operating characteristic (ROC) curve analysis, the optimal cutoff values were determined for the FAR, and the patients were divided into low (< 0.138) and high (≥ 0.138) FAR groups. C-reactive protein (CRP)- albumin ratio (CAR), procalcitonin-CRP ratio (PCR), prognostic nutritional index (PNI) were grouped based on a cutoff point of 0.646, 6.1 and 33.9 respectively. Cox regression analyses were used for evaluating prognostic significances for progression-free survival (PFS) and overall survival (OS) of parameters.

RESULTS

Both PFS (p<0.001, p: 0.027, p: 0.003, respectively ) and OS (p<0.001, p: 0.001, p<0.001, respectively) were found shorter in the group with higher FAR, CAR, PCR. Both PFS (p: 0.020) and OS (p: 0.001) were found to be longer in the group with higher PNI compared to the group with low PNI. In multivariate analysis, FAR and PNI were found as an independent prognostic factor for both PFS and OS (p: 0.039, p: 0.021; p: 0.034, p: 0.016, respectively).

DISCUSSION AND CONCLUSION

FAR and PNI are independent prognostic parameters predicting survival times in patients with SCLC.