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Primary Anorectal Malignant Melanoma: A Single Center Experience
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Original Article
VOLUME: 53 ISSUE: 1
P: 68-73
2020

Primary Anorectal Malignant Melanoma: A Single Center Experience

Acta Haematol Oncol Turc 2020;53(1):68-73
DOI: 10.5505/aot.2020.81594
Havva Yeşil Çınkır 1
Fatih Yıldız 2
Ferit Aslan 2
Ilkay Dogan 3
Ulku Yalcintas Arslan 2
Özlem Sönmez 2
Umut Demirci 2
Berna Öksüzoğlu 2
1. Gaziantep University Faculty Of Medicine, Department of Medical Oncology, Gaziantep, Turkey
2. Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Department of Medical Oncology, Ankara, Turkey
3. Gaziantep University Faculty Of Medicine, Department of Biostatistics, Gaziantep, Turkey
4.
No information available.
No information available
Received Date: 2019-05-21T13:01:54
Accepted Date: 2020-04-28T11:14:22
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Abstract

INTRODUCTION

Primary anorectal malignant melanoma (ARMM) is a rare tumor. Melanomas form 1% of anorectal carcinomas. The prognosis is poor, the 5-year survival rate is 10%. In our study, we evaluated patients with ARMM because of the rare tumor.

METHODS

The patient information of 21 patients with ARMM between October 1998 and February 2019 were retrospectively reviewed. Demographic, clinical, radiological and survival characteristics of the patients were recorded. Kaplan-Meier survival analysis was used for survival analysis.

RESULTS

The mean age of the patients was 59,5 ± 13,3 years (28-76); 8 (38,1%) were male and 13 (61,9%) were female gender. According to tumor localization, 8 (38,1%) anal region, 11 (52,4%) rectal region and 2 (9,5%) were located in the anorectal region. Overall survival (OS) was 16 months (95% Confidence Interval (CI); 13,2-18,7) according to survival analysis. According to the diagnosis of metastasis, the median OS in the early stage was 18 months (95% CI;15,6-20,3); 11 months (95% CI;4,5 ± 17,4) in metastatic disease (p: 0,003).

DISCUSSION AND CONCLUSION

The ARMM does not currently have any treatment guidelines, the choice of the therapeutic method should be carefully considered. Early diagnosis and a personalized, multidisciplinary treatment plan will probably improve the outcome of ARMM treatment.