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Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Patients With Locally Advanced Gastric Cancers
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Original Article
VOLUME: 55 ISSUE: 2
P: 116-127
2022

Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Patients With Locally Advanced Gastric Cancers

Acta Haematol Oncol Turc 2022;55(2):116-127
DOI: 10.5505/aot.2022.36450
Ahmet Karayiğit 1
Dursun Burak Özdemir 2
Hayrettin Dizen 3
Murat Ulas 4
1. Department of Surgical Oncology, SBU Adana City Training and Research Hospital, Adana, Turkey
2. Department of Surgical Oncology, SBU Samsun Training and Research Hospital, Samsun, Turkey
3. Department of General Surgery, Acibadem Eskisehir Hospital, Eskisehir, Turkey
4. Department of Surgical Oncology, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey
5.
No information available.
No information available
Received Date: 2021-12-23T12:23:32
Accepted Date: 2022-08-01T05:55:19
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Abstract

INTRODUCTION

This study aimed to determine the relationship between preoperative neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) levels with prognosis of locally advanced gastric cancers (GC).

METHODS

This was a retrospective single centre study conducted between January 2011 and January 2016 at the Department of General Surgery of XXX. A total of 83 patients histologically diagnosed with GC who received curative surgery were included in the study.

RESULTS

Median (first-third quartile) NLR value was 2.62 (1.93-4) and PLR value was 148.1 (117.73-221.43). ROC analysis did not yield optimal cut-off values for NLR and PLR to predict mortality. Lower overall survival rates were reported in GC patients with extracapsular invasion, perineural invasion, lymphovascular invasion, surgical margin positivity, various clinical findings (leakage, infection and recurrence), and lower albumin level (all, p<0.05). Cox regression analysis demonstrated that preoperative NLR and PLR were non-significant factors for mortality (p=0.302 and 0.147, respectively). Tumour size, perineural invasion, N3 stage, leakage and lower albumin level were independent prognostic determinants for mortality.

DISCUSSION AND CONCLUSION

Our results indicate that preoperative NLR and PLR were not associated with prognosis and could not be used as prognostic indicators for mortality in patients with GC. Greater tumour size, perineural invasion, N3 stage, leakage and hypoalbuminemia were significantly associated with prognosis. Further prospective studies with longer patient follow-up and larger sample sizes will help to verify our current data on prognostic indicators for GC.