Abstract
INTRODUCTION
We aimed to create subgroups in terms of tumor size, number and previous recurrence status in intermediate-risk non-muscle invasive bladder cancer (NMIBC) and evaluate the predictive roles of these parameters in determining recurrence.
METHODS
99 patients who were treated and followed up between January 2009 and December 2015 with the diagnosis of intermediate-risk NMIBC were retrospectively analyzed. Group I consisted of primary, single, Ta grade, low grade, > 3 cm tumors; Group II consisted of primary, Ta grade, low grade, <3 cm, multiple tumors and Group III consisted of recurrence of previous low-risk tumors. Three groups were compared in terms of clinical, pathological findings and recurrence in follow-up.
RESULTS
Mean age of patients was 65.73±12.21. Among them, 41 (41.4%) patients had recurrence in median 48 (15-84) monthly follow-up. Recurrence rate in Group III (58.8%) was significantly higher than Group I (29.6%) and Group II (34.2%) (p = 0.039). The predicted recurrence-free survival (36.1 months) in Group III was significantly lower than Group I (54.8 months) and Group II (61.2 months) (p=0.01 and p=0.003, respectively). In univariate analysis, the presence of previous recurrence, tumor size, number and CUETO score were reported as independent predictive factors for recurrence. In multivariate analysis, only the presence of previous recurrence was found to be significant.
DISCUSSION AND CONCLUSION
The subgroup analysis of intermediate-risk NMIBC may be helpful in determining tumor treatment and follow-up protocols.We state that new tumor recurrences may be higher in intermediate-risk NMIBC with previous recurrence history.