Abstract

INTRODUCTION

Prostate Cancer(PCa) is the most common cancer disease among men. The pathologic grade of tumor has an important place in patient’s treatment plan. In our study, we aimed to predict the increase in the tumor grade of prostatectomy specimens than biopsy degree in the patients who underwent Robot-Assisted Laparoscopic Radical Prostatectomy(RALRP) due to PCa diagnosis.

METHODS

The data of 109 patients who were diagnosed with PCa and underwent RALRP between August 2019 and May 2020 were analyzed retrospectively in our clinic. Surgical operations were carried out by Da Vinci Xi surgical robot system (Intuitive Surgical, Sunnyvale, CA, USA). The patients whose ISUP rating in post RALRP examination increased compared to the prostate biopsy were classified as group-1; patients remained same or decreased were classified as group-2. The patient’s age, prostate-specific antigen(PSA), prostate volume, rectal examination by palpation (DRE) findings, Neutrophil/ Lymphocyte ratio (NLR), Platelet/ Lymphocyte ratio(PLR) and AST/ALT (De Ritis) values were compared in these two groups.

RESULTS

The average age of patients included in this study was 64.32 ± 6.20 (46-77) years, the PSA value was 9,46±10,84 (0,5-86) ng/mL and prostate volume was 49.19 ± 25.72 ( 18-145) mL. Increase in tumor grade after RYLRP was detected in 33 (%36,7) patients, while the grade remained in 48 (%53,3) patients, 9 (%10) patients had a decrease. Although, age, PSA, pathological result ratio in DRE, NLR and De Ritis ratio were found higher in group-1 than group-2, this highness was not statistically significant (p>0,05). PLR was significantly higher in group 1 than group 2 (p=0,026).

DISCUSSION AND CONCLUSION

In our study, although only the increase in PLR was found to be statistically significant, all other parameters except for prostate volume were found to be high in the group with an increase in tumor grade.