Increased KLF5 gene expression in a Group of Turkish Gastric Adenocarcinoma Patients: Verification of HR-CGH results

Acta Haematol Oncol Turc 2019;52(1):1-9

DOI: 10.5505/aot.2019.42375

1. Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Clinic of General Surgery, Ankara, Turkey

2. Ankara University Brain Research Center, Ankara, Turkey

3. Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Gastroenterology, Ankara, Turkey

4. Ankara University School of Medicine Department of Medical Genetics, Ankara, Turkey

5. Ankara University School of Medicine Department of Surgical Oncology, Ankara, Turkey

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Received Date: 2019-01-23T22:11:52

Accepted Date: 2019-04-09T13:26:20

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Abstract

INTRODUCTION

In this study we aimed to investigate the diagnostic and prognostic significance of the expression level of KLF5 gene located frequently on amplified region of 13q21 in patients with gastric cancer.

METHODS

Thirty five patients with gastric adenocarcinomas were enrolled in this study and KLF5 mRNA were quantified by real-time qPCR both in normal and tumoral gastric tissue samples.

RESULTS

Our results showed that KLF5 is significantly over-expressed in tumor tissues than normal gastric mucosa samples (P<0.01). Fold change of KLF5 expression in patients with different degree of lymph node metastasis were found to be different at a level of limited statistical significance (P=0.052).Patients with increased lymph node metastasis had KLF5 over-expression when compared to patients with lower lymph node metastasis.

DISCUSSION AND CONCLUSION

Our results may contribute to expand the role of KLF5 in gastric tumor development and progression.