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Importance of neutrophil-lymphocyte ratio in the management of children with cervical lymphadenopathy
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Original Article
VOLUME: 52 ISSUE: 3
P: 470-476
2019

Importance of neutrophil-lymphocyte ratio in the management of children with cervical lymphadenopathy

Acta Haematol Oncol Turc 2019;52(3):470-476
DOI: 10.5505/aot.2019.82542
Selin Üstün Bezgin 1
Taliye Çakabay 1
Işık Odaman Al 2
Ali Aycicek 2
Ferhan Akıcı 2
Havva Duru İpek 1
1. Istanbul Kanuni Sultan Süleyman Education and Research Hospital, Otorhinolaryngology Department, Istanbul, Turkey
2. Istanbul Kanuni Sultan Süleyman Education and Research Hospital, Pediatric Hematology and Oncology Department, Istanbul, Turkey
3.
No information available.
No information available
Received Date: 2019-09-14T11:03:46
Accepted Date: 2019-12-27T14:31:31
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Abstract

INTRODUCTION

Cervical lymphadenopathy is a common presenting symptom in pediatric patients. The differentiation of malignant from benign causes and increasing the armamentarium of additional predictive factors is critically important. In this study, we aimed to assess the clinical importance of neutrophil-lymphocyte ratio in the evaluation of children with cervical lymphadenopathy.

METHODS

Eighty-six (n: 86) children (<18 years of age) were the subjects of this study. Three groups were assigned and group 1 as a control patients (n: 30) who underwent circumcision or inguinal hernia repair in our hospital. Group 2 (n=30) as a study group composed of patients who were examined in the otorhinolaryngology and/or pediatric hematology-oncology outpatient clinics due to chronic enlarged cervical lymph nodes. Group 3 (n=26) was composed of patients who were diagnosed with Hodgkin lymphoma. The neutrophil-lymphocyte ratio in the groups were analyzed.

RESULTS

There was significant differences between the mean neutrophil-lymphocyte ratios of group 1 and 3 (p <0.05) and group 2 and 3 (p <0.05) whereas no significant difference was found between group 1 and 2 (p >0.05). A receiver operating characteristic (ROC) curve analysis was performed based on the neutrophil-lymphocyte ratio value of 1.2 corresponded to the maximum combined sensitivity and specificity on the ROC curve and 40% sensitivity and 33% specificity were determined.

DISCUSSION AND CONCLUSION

Present study reveals higher neutrophil-lymphocyte ratio in lymphoma group than the others. However low specificity and sensitivity values restricts the use of a reliable parameter to detect malignancy.