Abstract

Tamoxifen use can cause gynecologic tumors like uterine sarcomas. However, the relationship between tamoxifen use and adult granulosa cell tumors (AGCTs) is uncertain. Here we report a case of AGCT in a 57-year old patient with antecedent tamoxifen use for hormone-receptor positive breast cancer. After 22 months of tamoxifen use, the patient had diagnosed with a stage 1a granulosa tumor. To our knowledge, there are only four cases previously published about the relationship between the development of granulosa cell tumors and the use of tamoxifen. It is very difficult to say that there is a certain relationship between tamoxifen use and AGCT because of the rarity of the condition.