Abstract

INTRODUCTION

Multiple Myeloma (MM) is the second most common hematologic malignancy. Genetic alterations in MM may affect structure or number of chromosomes. Specific translocations like t(11;14)(q13;q32), t(4;14)(p16;q32), t(14;16)(q23;q32), hypodiploidy, hyperdiploidy, deletion 13q (del 13q) or TP53 are some of the mutations observed in MM patients. In this study, we aimed to study the genetic alterations observed in Turkish patients with MM.

METHODS

The data of MM patients whose genetic evaluations were performed at our center between February 2014 and November 2019 were retrospectively analyzed. Only the patients whose bone marrow samples were evaluated by conventional cytogenetics and by fluorescence in situ hybridization (FISH) [t(4;14), t(11;14), del13q, TP53] were included in the study.

RESULTS

100 patients with MM were included in the study. 22 (22%) patients had genetic alterations at the time of diagnosis. The most often observed genetic alteration was del 13q which was observed in 12% of the patients. t(11;14), TP53, trisomy 7, t(4;14) and trisomy 8 were observed in 8%, 8%, 7%, 5% and 4% of MM patients, respectively.

DISCUSSION AND CONCLUSION

Evaluating the genetic characteristics of MM patients not only at the time of diagnosis but also during the follow up is crucial in order to optimize the treatment aproaches. Keywords: Multiple myeloma, genetic alterations, conventional cytogenetics