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Evaluation of the Response to Radiotherapy With Positron Emission Tomography/Computer Tomography in Head and Neck Carcinoma
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Original Article
VOLUME: 52 ISSUE: 1
P: 169-176
2019

Evaluation of the Response to Radiotherapy With Positron Emission Tomography/Computer Tomography in Head and Neck Carcinoma

Acta Haematol Oncol Turc 2019;52(1):169-176
DOI: 10.5505/aot.2019.47568
Esra Kekilli 1
Candaş Tunalı 2
1. Dr Abdurrahman Yurtaslan Ankara Oncology Training And Research Hospital, Ankara
2. Çukurova University Faculty Of Medicine. Radiation Oncology, Adana
3.
No information available.
No information available
Received Date: 2018-12-17T19:38:57
Accepted Date: 2019-04-09T13:57:57
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Abstract

INTRODUCTION

The aim of this study is to assessment of therapy response to radiotherapy or concurrent chemoradiotherapy in patients with head and neck carcinoma using with Positron Emission Tomography/Computer Tomography.

METHODS

36 head and neck cancer patients who were treated in our clinic between April 2009 and April 2011 were prospectively included this study. All patients were scanned with Positron Emission Tomography/Computer Tomography imaging before and after treatment and therapy response was evaluated by using standard uptake value max. Positron Emission Tomography/Computer Tomography results and biopsy that was taken from primary tumor as histopatologic assessing used for patients staging. This staging is based on American Joint Committee on Cancer 6.th edition.

RESULTS

Patients who were accepted this study were 32 male (88,9 %) and 4 female (11,1 %). The mean age of the patients was 57,5 (35-77) years. Mean follow up time was 13,5 months. Pretreatment mean of standard uptake value max was 11. High standard uptake values max (>11) predicted significantly worse treatment response as compared with low standard uptake value max (<11). Standard uptake value max was increased as the stage increased. At the end of the treatment standard uptake value max in early stage patients (0,002) was much more regressed than advanced stage patients (<0,001).

DISCUSSION AND CONCLUSION

In this study demonstrated that the patients with pretreatment high standard uptake value max had poorer treatment response. This study showed that pretreatment and the difference standard uptake values max are strong related with therapy response.