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Evaluation of the Relationship Between COX-2 and Ki-67 Expression and Tumor Grade and Cox-2, Ki-67 Expression in Astrocytomas
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Original Article
VOLUME: 53 ISSUE: 1
P: 130-139
2020

Evaluation of the Relationship Between COX-2 and Ki-67 Expression and Tumor Grade and Cox-2, Ki-67 Expression in Astrocytomas

Acta Haematol Oncol Turc 2020;53(1):130-139
DOI: 10.5505/aot.2020.67299
Aysun Gökce 1
Selda Seçkin 2
1. Department of Pathology, University of Health Science, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara
2. Retired, Pathology
3.
No information available.
No information available
Received Date: 2020-01-17T13:10:57
Accepted Date: 2020-04-28T11:26:27
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Abstract

INTRODUCTION

In the present study, COX-2 and Ki-67 expression were investigated in astrocytomas of different grade. Difference between the expressşon levels of these two markers and their relationship with each other were evaluated.

METHODS

A total of 60 surgical materials diagnosed as 20 grade II, 20 grade III, 20 grade IV astrocytoma retrospectively were included in the study. Ki-67 and COX-2 were studied by immunohistochemical method. Data analysis was performed using SPSS for Windows, version 11.5. Shapiro Wilk test, Mann Whitney U test, Kruskal Wallis test, and multiple comparison test were used.

RESULTS

The prevalence of COX-2 staining was higher in patients with grade III and IV astrocytoma than grade II (p <0.001 and p <0.001). There was no significant difference between grade III and IV astrocytomas in terms of COX-2 staining prevalence (p = 0.087). The number of cases stained with COX-2 in grade IV was higher than those of grade II and grade III (p <0.001 and p = 0.030). There was no significant difference between Grade II and Grade III astrocytomas in terms of COX-2 staining intensity (p = 0.198).Ki-67 index was higher in grade III and grade IV tumors compared to grade II and in grade IV tumors compared to grade III (p = 0.007, p <0.001, p <0.001). The Ki-67 index of the strongly stained group was higher than the group without COX-2 staining and weak staining group (p = 0.004 and p = 0.004). Ki-67 index was similar between unstained and poorly stained groups (p = 0.096).

DISCUSSION AND CONCLUSION

We conclude that COX-2 expression may play a role in the progression of astrocytomas, may be associated with more aggressive gliomas, and COX-2 inhibitors may have a therapeutic role in addition to the existing treatment protocols of astrocytomas, and Ki-67 immunostaining might be effective in differentiating tumors of different grades.