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Evaluation of Factors Associated With Retinal Hemorrhage In Patients With Acute Leukemia
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Original Article
VOLUME: 55 ISSUE: 2
P: 174-179
2022

Evaluation of Factors Associated With Retinal Hemorrhage In Patients With Acute Leukemia

Acta Haematol Oncol Turc 2022;55(2):174-179
DOI: 10.5505/aot.2022.97992
Sibel Özdogan 1
Ayşenur Çelik 1
Semih Başcı 2
1. Department Of Ophthalmology, Dr. Abdurrahman Yurtaslan Oncology Training And Research Hospital, University Of Health Sciences, Urankent, Yenimahalle, Ankara, Türkiye.
2. Department Of Hematology And Bone Marrow Transplantation Center, Dr. Abdurrahman Yurtaslan Oncology Training And Research Hospital, University Of Health Sciences, Urankent, Yenimahalle, Ankara, Türkiye
3.
No information available.
No information available
Received Date: 2022-04-08T18:46:15
Accepted Date: 2022-08-01T05:57:46
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Abstract

INTRODUCTION

We aimed to investigate the association of retinal hemorrhage and blood parameters in patients with acute leukemia

METHODS

We have retrospectively investigated sixty-one acute leukemia patients with and without retinal hemorrhages and analyzed associated factors. Patients underwent a detailed ocular examination. The hematological and coagulation parameters were based on data when the retinal hemorrhages were noticed in the fundus.

RESULTS

The study group consisted of 30 patients with acute myelocytic leukemia (AML) and acute lymphocytic leukemia (ALL) who had retinal hemorrhages and the control group consisted of 31 patients with acute leukemia without retinal hemorrhages. Approximately ½ of the patients had low vision due to retinal hemorrhage, while the other half were detected by meticulous eye examination. AML diagnosis was statistically more frequent in patients with retinal hemorrhage (p=0.02). Active disease was statistically more common in the patients with retinal hemorrhage (p=0.03). In the retinal hemorrhage group, patients had significantly lower hemoglobin, hematocrit, and platelet levels than those without hemorrhages (p=0.001, p=0.001 and p=0.001 respectively). There was no statistically significant difference in leukocytes values between two groups (p=0.634).

DISCUSSION AND CONCLUSION

In present study we found correlation between the hematological parameters and retinal hemorrhages. In patients with active AML and profound thrombocytopenia, a visual examination should be prioritized since ocular problems may go unnoticed since many patients are asymptomatic.