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E-ISSN: 3061-9947
Evaluation of Bone Mineral Densitometry Measurements in Patients with BCR/ABL-Negative Chronic Myeloproliferative Neoplasm
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Original Article
VOLUME: 54 ISSUE: 2
P: 159-165
2021

Evaluation of Bone Mineral Densitometry Measurements in Patients with BCR/ABL-Negative Chronic Myeloproliferative Neoplasm

Acta Haematol Oncol Turc 2021;54(2):159-165
DOI: 10.5505/aot.2021.72324
Aysun Şentürk Yıkılmaz 1
Sema Akıncı 2
Şule Mine Bakanay 1
Selin Küçükyurt Kaya 2
İmdat Dilek 1
1. Yildirim Beyazit University, Hematology Department, Ankara, Turkey
2. Department of Hematology, Bilkent City Hospital, Ankara, Turkey
3.
No information available.
No information available
Received Date: 2020-10-27T09:58:54
Accepted Date: 2021-08-11T08:32:45
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Abstract

INTRODUCTION

This study aims to determine the changes in and the factors related to the bone mineral density in patients with BCR/ABL-negative chronic myeloproliferative neoplasm (CMPD).

METHODS

The data of 38 males (52.1%) and 35 females (47.9%) patients diagnosed with CMPD were analyzed retrospectively. The age, gender, diagnosis (polycythemia vera (PV), essential thrombocythemia (ET)), JAK2V617F mutation positivity, the presence of the CMPD complications and the bone mineral densitometry (BMD) measurements of femur neck and lumbar spine carried out during the diagnosis were recorded for each patient. The patients were divided into four groups: under 65 and over 65 years old for men, premenopausal and postmenopausal status for women. They were also grouped according to the T score of the femur neck and lumbar spine with normal and decreased bone density.

RESULTS

Female patients were found to have more bone loss in the lumbar spine (p=0.031). In female patients, the reduction in the lumbar spine BMD was greater in the postmenopausal group (p=0.012). The decrease in bone density in the femur neck was found to be greater in the group above 65 years of age (p=0.01). There was no relationship between BMD and ET, PV, JAK2V617F mutation positivity, and CMPD complications such as thrombosis and hemorrhage.

DISCUSSION AND CONCLUSION

According to the results obtained in our study, the presence of CMPD increases bone loss in lomber area in female patients. Therefore, the BMD measurement and calcium-D supportive treatment planning in the premenopausal group are thought to be beneficial in female patients.