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Effects of intraperitoneal administration of simvastatin on collagen deposition, inflammation level and wound tension in an experimental incisional wound model
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Original Article
VOLUME: 53 ISSUE: 1
P: 181-188
2020

Effects of intraperitoneal administration of simvastatin on collagen deposition, inflammation level and wound tension in an experimental incisional wound model

Acta Haematol Oncol Turc 2020;53(1):181-188
DOI: 10.5505/aot.2020.16768
Ömer Arda Çetinkaya 1
Süleyman Utku Çelik 2
Nesrin Hasırcı 3
Mehmet Gürel 1
1. Department of General Surgery, Ankara University School of Medicine, Ankara, Turkey
2. Department of General Surgery, Gulhane Training and Research Hospital, Ankara Turkey
3. Department of Chemistry, Middle East Technical University, Ankara, Turkey
4.
No information available.
No information available
Received Date: 2019-12-19T00:44:23
Accepted Date: 2020-05-14T14:55:27
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Abstract

INTRODUCTION

Wound healing is an important component of all surgical operations. In this study, we aimed to investigate the effects of intraperitoneal administration of simvastatin on collagen deposition, inflammation level, and wound tension in an experimental wound healing model.

METHODS

The study was carried out on 36 rats, divided into three groups. The primary repair of abdominal wall midline incision was determined as a wound-healing model. High-dose simvastatin (5 mg/kg/day) was administered intraperitoneally for 14 days preoperatively in group 1, low-dose of simvastatin (1 mg/kg/day) was administered in group 2 rats, and the placebo solution was given to group 3. Rats were compared in terms of tensile strength, level of collagen, and inflammation scores.

RESULTS

Although tensile strength of rats in group 1 was lower than those in other groups, this difference was not significant (p = 0.058). Type I and type III collagen level were significantly different between groups (p = 0.011 and p = 0.002; respectively). The post-hoc test revealed that group 1 rats had significantly higher type I collagen level than those of group 3 rats (2.18 ± 0.75 vs. 1.25 ± 0.45; p = 0.006). The type III collagen in group 1 and group 2 were also significantly higher than that in group 3 (2.27 ± 0.78 vs. 1.16 ± 0.38, p = 0.002; 1.90 ± 0.70 vs. 1.16 ± 0.38; p = 0.015). However, inflammation scores were not different between the groups (p = 0.186).

DISCUSSION AND CONCLUSION

Although high-dose simvastatin significantly increased type I and type III collagen levels; tensile strength and inflammation score among the three groups of rats were not significantly different.