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Comparison of 3 Different Methods in The Antibiotic Prophylaxis for Prostate Biopsy
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Original Article
VOLUME: 53 ISSUE: 1
P: 57-61
2020

Comparison of 3 Different Methods in The Antibiotic Prophylaxis for Prostate Biopsy

Acta Haematol Oncol Turc 2020;53(1):57-61
DOI: 10.5505/aot.2020.70446
Gökhan Sönmez 1
Fatih Demir 1
Murat Keske 1
Nurullah Hamidi 2
Mert Ali Karadağ 1
1. Department Of Urology, Kayseri City Hospital, Kayseri, Turkey
2. Departmen Of Urology, Atatürk Training And Research Hospital, Ankara, Turkey
3.
No information available.
No information available
Received Date: 2019-05-14T11:32:17
Accepted Date: 2020-04-28T11:12:16
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Abstract

INTRODUCTION

The gold standard method for the definitive diagnosis of Prostate Cancer (PCa) is prostate needle biopsy (PB). Significant life-threatening complications such as urinary tract infections may occur after PB. The aim of this study was to compare the efficacy of ciprofloxacin, gentamicin and ciprofloxacin+gentamicin in PB prophylaxis.

METHODS

In this retrospective study, the data of patients who underwent standard 10-12 core prostate biopsy under the guidance of transrectal ultrasonography because of the suspicion of prostate cancer were analyzed. Patients were divided into 3 groups according to the applied prophylaxis method; 1) Single dose im. gentamicin 160 mg administered before biopsy. 2) Ciprofloxacin 500 mg administered twice a day for a total of 3 days (oral) starting 24 hours before biopsy. 3) The combination of both drugs applied. Febrile urinary tract infection (FUTI) rates of the groups, as well as some demographic and clinical data such as age, serum prostate specific antigen (PSA) levels, were recorded and compared.

RESULTS

A total of 180 patients were included in the study (group 1= 67, group 2=51, group 3= 62 patients). The mean age of all patients was 64.41 (+/-7.08) years. The incidence of FUTI after biopsy was 4.4%. The mean age, median prostate volumes, median PSA levels and cancer detection rates of the groups were statistically similar. While the most number of FUTIs were detected in Group-2 (11.7%), Group-1 and Group-3 were similar in terms of FUTI rates (1.4%, 1.6%, respectively). The most commonly isolated agent was Escherichia Coli.

DISCUSSION AND CONCLUSION

According to the results of our study, a single dose im. prophylaxis with gentamicin appears to be a more effective prophylaxis method than antibiotic prophylaxis with oral ciprofloxacin alone. Although the effectiveness of single-dose gentamicin and combination prophylaxis are similar, because of the ease of administration and the choice of rational antibiotics, we recommend single-dose gentamicin.