EN | TR
E-ISSN: 3061-9947
ASSESSMENT of HEMATOLOGICAL PARAMETERS BEFORE and AFTER ADJUVANT CHEMOTHERAPY in PATIENTS with COLORECTAL CANCER
PDF
Cite
Share
Request
Original Article
VOLUME: 52 ISSUE: 3
P: 405-409
2019

ASSESSMENT of HEMATOLOGICAL PARAMETERS BEFORE and AFTER ADJUVANT CHEMOTHERAPY in PATIENTS with COLORECTAL CANCER

Acta Haematol Oncol Turc 2019;52(3):405-409
DOI: 10.5505/aot.2019.20982
Fevzi Coşkun Sökmen 1
Benan Kasapoğlu 2
Ahmet Yozgat 2
Hüseyin Engin 3
1. University of Health Sciences, Dr Abdurrahman Yurtaslan Oncology Education and Research Hospital, Department of Internal Medicine, Ankara, Turkey
2. University of Health Sciences, Dr Abdurrahman Yurtaslan Oncology Education and Research Hospital, Department of Gatroenterology, Ankara, Turkey
3. Bulent Ecevit University Practice and Research Hospital, Medical Oncology, Zonguldak, Turkey
4.
No information available.
No information available
Received Date: 2019-08-21T01:20:00
Accepted Date: 2019-12-27T14:24:20
PDF
Cite
Share
Request

Abstract

INTRODUCTION

Aim: In this study we aimed to evaluate the alterations in hematological parameters due to the adjuvant chemotherapy treatment in patients with colorectal cancer.

METHODS

Material and Method: In a total of 140 cases diagnosed with colorectal cancer were evaluated and among those patients 57 received adjuvant chemotherapy. Alterations in complete blood count parameters after adjuvant chemotherapy were evaluated. .

RESULTS

Results: Among participants, 67 (47.9%) were women and 73 (52.1%) were men with a mean age of 62.13 ± 1.11 years. The most common tumor localization was rectum (45.7%). Among these patients 57 received adjuvant chemotherapy (40.7%), the most frequently implemented chemotherapy regimen was Mayo regimen (84.2%). 27.9% of our cases had metastasis at the time of diagnosis. During clinical follow-up 10.7% of the patients had local relapse and 7.8% had metastasis. Hemoglobin (HGB) levels displayed a significant decrease both in patients who received blood transfusion or not, however this was more evident in the group of patients with no previous transfusion (p=0.002). Following the adjuvant chemotherapy, white blood cell values (WBC), mean erythrocyte volumes (MCV) and thrombocyte (PLT) levels were found to decrease significantly without any interaction with modifying components (metastasis development, chemotherapy implementation duration, blood transfusion) (p values 0.002, 0.001 and 0.001 respectively) while red cell distribution width (RDW) had increased significantly (p=0.001).

DISCUSSION AND CONCLUSION

Conclusion: There was a significant decrease in Hgb, MCV, WBC and platelet levels and a significant increase in RDW after adjuvant chemotherapy and these alterations were not affected by the presence of metastasis or duration of chemotherapy. The association of these alterations in blood parameters with the prognosis of patients should be investigated in further studies