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Are platelet and eosinophil parameters indicators of predicting the development of erectile dysfunction after radical prostatectomy?
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Original Article
VOLUME: 52 ISSUE: 1
P: 136-143
2019

Are platelet and eosinophil parameters indicators of predicting the development of erectile dysfunction after radical prostatectomy?

Acta Haematol Oncol Turc 2019;52(1):136-143
DOI: 10.5505/aot.2019.75436
İsmail Selvi 1
Erdem Öztürk 2
1. Department of Urology, Karabük University Training and Research Hospital
2. Department of Urology, Health Sciences University Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
3.
No information available.
No information available
Received Date: 2019-03-06T21:40:21
Accepted Date: 2019-04-09T13:40:36
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Abstract

INTRODUCTION

Erectile dysfunction(ED) may develop in 14-90% following radical prostatectomy(RP). Development of ED is due to neurovascular damage during surgery. In our study, we aimed to evaluate whether the platelet and eosinophil parameters are prognostic factors in predicting ED after prostatectomy.

METHODS

Data of 181 patients who underwent RP between January 2010 and December 2016 were analyzed retrospectively. In the preoperative period, platelet count, mean platelet volume (MPV), platelet distribution width (PDW) and eosinophil count were recorded. The patients were evaluated for ED according to the International Erectile Function Index in preoperatively and postoperatively. In the postoperative 12th month, ED was observed in 128 patients following RP. Among them, 82 patients with postoperative ED were included in Group I, and 46 patients without postoperative ED were included in Group II.

RESULTS

Age (p=0.281) and body mass index (p=0.851) had no significant difference between groups. In preoperative period, mean platelet count (292.18±51.62 vs. 240.15±46.25, p<0.001), mean MPV value (8.77±1.24 vs. 6.17±0.87, p<0.001) and mean eosinophil count (0.57±0.16 vs. 0.47±0.10, p<0.001) were higher in Group I. Mean PDW value (16.21±1.84 vs.16.75±1.77, p=0.110) had no significantly difference. According to ROC analysis, the cut-off values for platelet, MPV and eosinophil were 242 (AUC: 0.783, p<0.001), 7.24 (AUC: 0.951, p<0.001) and 0.5 (AUC: 0.675, p=0.001), respectively. In multivariate analysis, MPV and eosinophil were found to be more important independent factors in predicting ED after RP.

DISCUSSION AND CONCLUSION

It is shown that platelet, MPV and eosinophil are independent predictive factors in predicting ED following prostatectomy.