Abstract

Background: Brenner tumor of ovary is a rare neoplasm which constitutes almost 1 percent of all ovarian tumors. These tumors are usually benign, with only 1% being malignant. Here, we report a very rare case of bilateral malignant Brenner tumor. Case: A 55 year-old woman admitted to our center with complaints of abdominal distention and pain. Her physical examination was remarkable for pelvic mass and ascites. Sonographic examination showed a complicated pelvic mass of ovarian origin. Her preoperative serum CA-125 level was 64 IU/ml. An exploratory laparotomy revealed bilateral ovarian masses and frozen section of the ovarian tumors was reported to be malignant. There was no peritoneal disease and she underwent a standard staging procedure. Final pathology revealed FIGO 2009 stage IIIC bilateral malignant Brenner tumor of the ovary. Patient received 6 cycles of platinum based chemotherapy. After 13 months of diagnosis multiple metastatic lesions in lungs were found and she underwent salvage chemotherapy. She received multiple chemotherapy regimens however disease progressed gradually and she succumbed to disease 53 months after initial diagnosis. Discussion: In the vast majority of ovarian Brenner tumors, surgical resection provides a cure for benign disease. Owing to its low incidence there is not established adjuvant treatment algorithm for malignant ovarian Brenner tumors. Multicenter trials of ovarian cancer should aim to include this rare pathology to increase our knowledge.