Liposarcoma of The Lower Extremity: A Single Center Experience of 59 Patients

OBJECTIVE: The purpose of this study is to give the information on the outcome, management and survivability of patients with low extremity liposarcoma.
METHODS: This study is a retrospective study. All the patients were seen and managed between 1986 and 2010. Their records were retrieved and analyzed for this study. Fiftynine cases were identified to have the follow up of minimum 5 years and complete documentation.
RESULTS: In our study, the most common variant of the liposarcom is mixoid liposarcoma in spite of literature. Ten patients who have low grade liposarcom were treated with marginal resection. Recurrence wasn’t observed. We didn’t perform neoadjuvant radiotherapy. Two patients who have high grade liposarcoma underwent neoadjuvant chemotherapy. Adjuvant radiotherapy was given 49 patient who have intermediate or high grade liposarcoma. Four patients who have high grade liposarcoma were presented with lung metastases. Two patients who have myxoid liposarcoma were presented with extremity metastates.
CONCLUSION: We thought that, low grade liposarcomas had been treated at other small clinics as lipom so in our series the myxoid liposarcoma is the most common subtype. Neoadjuvant radiotherapy can get difficult surgery done. Recurrence usually was presented in two years after first surgery. So patients must be followed frequently during two years.

Alt Ekstremite Liposarkomlarý; Ellidokuz Hastalýk Tek Klinik Serisi

AMAÇ: Bu çalýþmada alt ekstremite liposarkomlarý hakkýnda bilgi vermek,tedavi yönetimi ve hastalarýn ortalam yaþam süreleri hakkýnda klinik tecrübelerimizin paylaþýlmasý amaçlanmýþtýr.
YÖNTEMLER: Retrospektif bir çalýþmadýr.1986-2010 yýllarý arasýnda minimum takip süresi 5 yýl ve daha fazla olan 59 hastanýn dosyalarý ve radyolojik görünütleri incelenmiþtir.
BULGULAR: Bizim çalýþmamýzda literatürün aksine en sýk görülen liposarkom alttipi miksoid liposarkom oalrak belirlenmiþtir. Low grade liposarkom olan 10 hasta sadece marginal rezeksiyon ile tedavi edilip nüks izlenmemiþtir. Hiçbir hastaya neoadjuvan radyoterapi verilmemiþtir. Adjuvan Radyoterapi ise intermediate grade ve high grade liposarkom olan diðer 49 hastaya verilmiþtir. High grade liposarkom olan 4 hastada akciðer metastazý gözlenmiþtir. Miksoid lposarkom olan 2 hastada ise ekstremite metastazý gözlenmiþtir.
SONUÇ: Miksoid liposarkom alttipinin kliniðimizde en fazla oranda görülmesinin sebebinin, low grade liposarkomlarýn lipom gibi birçok kinikte tedavisinin yapýlmasý olarak düþünüyoruz. Neoadjuvan radyoterapinin cerrahiyi tedaviyi zorlaþtýrabileceðinden verilmemiþtir. Nükslerin çoðunlukla ilk 2 yýl içinde görülmektedir bundan dolayý ilk 2 yýl boyunca hastalarýn sýký takip edilmelidir.