The Relationship Between Pancreatic Neuroendocrine Carcinoma and Depression: May Depressive Symptoms Predict Metastasis?

Various studies were reported remarkable higher rates of depression in cancer patients. As a prototype, close relationship between cancer and major depression was reported in pancreatic cancer patients markedly and this relationship has been known for long years. Higher incidence of major depression exists in various subtypes of cancer, too. However, there is an inadequate data about this relationship and its underlying pathophysiological mechanism. In this paper, we have reported a case of whom had depressive symptoms before the diagnosis of pancreatic neuroendocrine pancreatic carcinoma and became more prominent at the time of progression of the disease. We have aimed to discuss about the probable relationship between depressive symptoms with early cancer diagnosis and prognosis and come up with the question of 'may depressive symptoms predict metastasis? '.

Pankreas Nöroendokrin Karsinomu ve Depresyon Arasýndaki Ýliþki: Depresif Belirtiler Metastazý Haber Verebilir mi?

Birçok çalýþmada, kanser hastalarýnda depresyon sýklýðýnýn belirgin olarak yüksek olduðu belirtilmiþtir. Bir prototip olarak kanser ve majör depresyon iliþkisi en belirgin þekliyle pankreas kanserinde karþýmýza çýkar ve bu güçlü iliþki uzun yýllardýr bilinmektedir Ancak bu iliþki ve iliþkinin altýnda yatan patofizyolojik mekanizma hakkýnda yetersiz bilgi birikimi söz konusudur. Farklý kanser türlerinde de artmýþ majör depresyon sýklýðý mevcuttur. Bu yazýda taný öncesinde depresif bulgularý ortaya çýkan ve hastalýk progresyonu döneminde bu bulgularý belirgin þekilde artan pankreatik nöroendokrin karsinom tanýlý bir vaka sunulmuþtur. Depresif bulgularla; malignite tanýsý ve prognoz arasýndaki olasý iliþkinin tartýþýlmasý ve 'depresif semptomlar metastazý öngörebilir mi?' sorusunun gündeme getirilmesi amaçlanmýþtýr.