Can Preoperative Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and APRI Score Reliably Differentiate Uterine Sarcomas from Leiomyomas?

Ert�rk Aksakal, Sezin; Korkmaz, Hilal; Korkmaz, Vakkas

pdf

Volume : Issue : Year : 2024

57/1Current Issue Ahead of Print Archive Most Accessed Articles

Turkish Journal of Bioethics

Can Preoperative Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and APRI Score Reliably Differentiate Uterine Sarcomas from Leiomyomas? [Acta Oncol Tur.]

Acta Oncol Tur.. 2022; 55(2): 85-92 | DOI: 10.5505/aot.2022.50570

Can Preoperative Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and APRI Score Reliably Differentiate Uterine Sarcomas from Leiomyomas?

Sezin Ert�rk Aksakal¹, Hilal Korkmaz², Vakkas Korkmaz³
¹Department of Gynecology, University of Health Sciences Etlik Zubeyde Hanim Women�s Health Training And Research Hospital, Ankara
²Department of Physiology, Gazi University Faculty of Medicine, Ankara
³Depertment of Gynecologic Oncology, University of Health Sciences Etlik Zubeyde Hanim Women�s Health Training And Research Hospital, Ankara

INTRODUCTION: Uterin sarcomas are one of the agresive gynecologic malignencies. There is still no optimal test for preoperative diagnosis of uterin sarcomas. The aim of this study was to evaluate the role of NLR, PLR, and APRI score in predicting preoperative uterine sarcoma.

METHODS: Patients operated on between January 2010 and December 2020 histopathologically diagnosed as sarcoma were included in the study group. Patients who were histopathologically diagnosed with M. uteri were included as the control group during the same period. Age, BMI (body mass index), gravida, parity, preoperative mean platelet volume (MPV), platelet distribution width (PDW), red cell distribution width (RDW), NLR,PLR and APR� scores were recorded.

RESULTS: When comparing patients with fibroids and sarcomas, hemoglobin [12.3 g/dl (6.4-15.4) vs. 11.3 g/dl (6-17), p=0.008, respectively], hematocrit [38.5% (22-48.7) vs. 35.9% (21.4-52.1), p=0.002, respectively] and lymphocyte levels [2.2 103/ L (0.9-13.8) vs. 1.8 103/ L (1-2.6), p 0.001, respectively] were significantly lower and NLR [1.7 (0.2-10.1) vs. 2.3 (1.4-5.9), p 0.001, respectively] and PLR [124 (10.9-352.1) vs. 180.4 (84.9-284.3), p 0.001, respectively] were significantly higher in sarcoma group. The optimal cut-off value for NLR and PLR was calculated to be 2.04 with sensitivity and specificity of 59.4% and 59.5%, respectively, and 150.7 with sensitivity and specificity of 65.6% and 64.7%, respectively.
DISCUSSION AND CONCLUSION: Preoperative NLR and PLR rates can be useful markers for diagnosing uterine sarcoma. Randomized controlled large series studies are necessary to make a definitive statement.

Keywords: Uterine sarcoma, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, APRI score

Preoperatif N�trofil Lenfosit Oran�, Platelet Lenfosit Oran� ve APR� Skoru Uterin Sarkomlar� Myomlardan Ay�rt Edebilir mi?

Sezin Ert�rk Aksakal¹, Hilal Korkmaz², Vakkas Korkmaz³
¹Jinekoloji Klini�i, Sa�l�k Bilimleri �niversitesi Etlik Z�beyde Han�m Kad�n Hastal�klar� E�itim Ve Ara�t�rma Hastanesi, Ankara
²Fizyoloji Anabilim Dal�, Gazi �niversitesi T�p Fak�ltesi, Ankara
³Jinekolojik Onkoloji Klini�i, Sa�l�k Bilimleri �niversitesi Etlik Z�beyde Han�m Kad�n Hastal�klar� E�itim Ve Ara�t�rma Hastanesi, Ankara

G�R�� ve AMA�: Uterin sarkomlar nadir g�r�len, agresif seyirli jinekolojik kanserlerden biridir. Preoperatif optimal tan� testi hala bulunmamaktad�r. �al��mam�z�n amac� preoperatif uterin sarkomu �ng�rmede n�trofil-lenfosit oran� (NLR), platelet-lenfosit oran� (PLR) ve APR� skoru de�erlendirmektir.
Y�NTEM ve GERE�LER: Ocak 2010 ile Aral�k 2020 tarihleri aras�nda histopatolojik sarkom tan�s� alan hastalar �al��maya dahil edildi. Ayn� d�nemde histopatolojik myom uteri tan�s� alan hastalar kontrol grubu olarak al�nd�. Ya�, v�cut kitle indeksi, gravida, parite, preoperatif ortalama platelet hacmi (MPV), platelet da��l�m geni�li�i (PDW), k�rm�z� h�cre da��l�m geni�li�i (RDW), NLR, PLR and APR� skoru kaydedildi.
BULGULAR: Sarkom ve myom tan�l� hastalar kar��la�t�r�ld��nda, sarkom hastalar�nda hemoglobin [s�ras�yla 12.3 gr/dl (6.4-15.4) ve 11.3 gr/dl (6-17), p=0.008, ], hematokrit [s�ras�yla %38.5 (22-48.7) ve %35.9 (21.4-52.1), p=0.002,] ve lenfosit seviyeleri [s�ras�yla 2.2 103/ L (0.9-13.8) ve 1.8 103/ L (1-2.6), p 0.001,] anlaml� olarak d��k, NLR [s�ras�yla 1.7 (0.2-10.1) ve 2.3 (1.4-5.9), p 0.001,] ve PLR [s�ras�yla 124 (10.9-352.1) ve 180.4 (84.9-284.3), p 0.001,] anlaml� olarak y�ksek saptand�.
TARTI�MA ve SONU�: Preoperatif NLR ve PLR oranlar� uterin sarkom tan�s�nda kullan�labilecek mark�rlard�r. Bu konuda kesin konu�abilmek ad�na randomize kontroll� geni� serili �al��malara ihtiya� vard�r.

Anahtar Kelimeler: Uterin sarkom, n�trofil lenfosit oran�, platelet lenfosit oran�, APR� skoru

Sezin Ert�rk Aksakal, Hilal Korkmaz, Vakkas Korkmaz. Can Preoperative Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and APRI Score Reliably Differentiate Uterine Sarcomas from Leiomyomas?. Acta Oncol Tur.. 2022; 55(2): 85-92

Corresponding Author: Sezin Ert�rk Aksakal, T�rkiye
Manuscript Language: English

TOOLS Full Text PDF Print Download citation RIS EndNote BibTex Medlars Procite Reference Manager Share with email Share Send email to author Similar articles PubMed Google Scholar

Quick Search

Can Preoperative Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and APRI Score Reliably Differentiate Uterine Sarcomas from Leiomyomas?

Preoperatif N�trofil Lenfosit Oran�, Platelet Lenfosit Oran� ve APR� Skoru Uterin Sarkomlar� Myomlardan Ay�rt Edebilir mi?