A Case of Metastatic Malignant Melanoma who Lung Progressed During Vemurafenib Treatment

A 70 year-old women admitted to our hospital with a swelling and discharge of the right inguinal site. Biopsy results was consisted with malignant melanoma. Imaging of thorax and abdomen showed metastatic disease. After first-line temozolamide treatment, palliative radiotherapy was applied to primary site because of progression. After detection of BRAF-V600E mutation, vemurafenib treatment was initiated. Treatment response to vemurafenib was very good partial response after second months of the treatment. Although locally progression of the left lung was seen after fifth months of therapy, partial response remained on the other sites, she was still on the treatment with vemurafenib.

Vemurafenib Tedavisi Sýrasýnda Akciðer Progresyonu Gösteren Metastatik Malign Melanom Olgusu

Yetmiþ yaþýnda kadýn sað inguinal bölgede akýntýlý þiþliði olmasý üzerine baþvurdu. Lezyon biyopsisi malign melanomla uyumluydu. Toraks ve batýn görüntülemelerinde metastaz bulgularý mevcuttu. Birinci basamak temozolomid sonrasý lezyon bölgesinde progresyon nedeni ile palyatif radyoterapi uygulandý. BRAF-V600E mutasyonu nedeni ile vemurafenib baþlandý. Tedavinin ikinci ayýnda çok iyi kýsmi yanýt elde edildi. Tedavinin 5. ayýnda sol akciðerde lokal progresyon izlenirken diðer bölgelerde kýsmi yanýtý devam ediyordu. Palyatif radyoterapi sonrasý vemurafenib tedavisine devam edildi.