Relation Between mTOR Status, Survival and Tumor Characteristics In Patients With Advanced Gastric Carcinoma

OBJECTIVE: Expression of mTOR have been linked to clinical outcomes in several solid tumors. However clinical significance of this biomarker in gastric cancer remain unclear. This study was designed to detect the clinical implications of this biomarker in Turkish population.
METHODS: Paraffin -embedded tissue microarray blocks containing gastric cancer tissue obtained from 30 patients were constructed. Expression of mTOR, were detected by immunohistochemistry.
RESULTS: The correlation of this biomarker to clinicopathologic features and survival of patients with gastric cancer was studied. The overall rate of positive mTOR, status were 36.7%.
CONCLUSION: There was no association was noted between the expression of mTOR and survival time.

Ýleri Evre Mide Kanserli Hastalarda mTOR Durumunun Saðkalým ve Tümör Karakteristikleri ile Ýliþkisi

AMAÇ: mTOR ekspresyonu birçok solid tümörde klinik sonuçlarla iliþkilidir. Bununla birlikte
mide kanserindeki klinik önemi henüz netleþmemiþtir. Bu çalýþma bu biyobelirteçin Türk toplumundaki klinik önemini belirlemek için tasarlanmýþtýr.
YÖNTEMLER: 30 hastanýn mide kanser dokusu içeren parafin kaplý doku bloklarý hazýrlanmýþtýr. Ýmmünhistokimyasal olarak mTOR ekspresyonu incelenmiþtir.
BULGULAR: Bu biyobelirteçin mide kanserli hastalardaki klinikopatolojik özellikleri ve saðkalýmlarý ile olan korelasyonu çalýþýlmýþtýr. mTOR pozitiflik durumu genel olarak %36.7 idi.
SONUÇ: Saðkalým süresi ve mTOR ekspresyonu arasýnda iliþki bulunmamýþtýr.