Lymphadenopathy of A Newborn: Langerhans Cell Histiocytosis

Langerhans cell histiocytosis (LCH) is a rare disorder of myeloid dendritic cells with an unknown etiology. It may cause localized bone and skin lesions also may be so widespread that the involvement can lead to multiple organ failure. In the neonatal period, patients with LCH is often diagnosed by skin lesions. In the first application of the patient, lymphadenopathy is not an expected finding.
A 35 day old male patient was admitted to our hospital with a presumptive diagnosis of mass in the neck? lymphadenopathy (LAP). His complaints had begun when he was 10 days old and despite the taken treatment, swelling in the neck was ongoing. It was evaluated as lymphadenitis? lymphoma? with cervical ultrasonography. LCH was reported as a result of the biopsy taken from LAP.
In this age group without accompanying cutaneous manifestations, the first complaint as LAP in patients diagnosed with LCH is rare in the literature. During the neonatal period, a good evaluation of the LAP must be done and it should be kept in mind that clinical and ultrasound images of LCH may interfere with infection and malignancy.

Yenidoðanda Lenfadenopati: Langerhans Hücreli Histiositozis

Langerhans hücreli histiositozis (LHH) etyolojisi tam bilinmeyen, myeloid dentritik hücrelerin nadir bir bozukluðudur. Lokalize kemik ve cilt lezyonlarý yapabileceði gibi multi organ yetmezliðine neden olabilecek kadar yaygýn tutulum da yapabilir. Yenidoðan döneminde LHH’li hastalar sýklýkla cilt bulgusu ile taný almaktadýr. Hastalarýn ilk baþvuru da lenfadenopati ile baþvurmasý sýk görülmemektedir.
Boyunda kitle? lenadenopati(LAP)? ön tanýlarý ile 35 günlük erkek hasta hastanemize baþvurdu. Hastanýn þikâyetleri 10 günlükken baþlamýþtý ve almýþ olduðu tedavilere raðmen boyundaki þiþlik geçmemiþti. Boyun ultrasonografisinde lenfadenit?, lenfoma? olarak deðerlendirildi. Hastanýn LAP’den alýnan biyopsi sonucu LHH olarak raporlandý.
Bu yaþ grubunda deri bulgusu eþlik etmeden, ilk baþvuru þikâyeti LAP olup LHH tanýsý koyulan literatürdeki nadir vakalardandýr. Yenidoðan dönemindeki LAP’lerin çok iyi deðerlendirilmesi, klinik ve ultrason görüntüsü ile LHH’un enfeksiyon ve malignite ile karýþabileceði akýlda tutulmalýdýr.