Right predilection of lung cancer, does it affect oncologic outcome?

INTRODUCTION: Lung cancer (LC) is the most common malignities and still remain the leading cause of cancer deaths. The aims of this study are to assess the effect of cigarette smoking on the localization and effect of the location of tumors on the prognosis and acute adverse effects.
METHODS: 72 patients that given curative thoracic radiotherapy between 24.11.11-14.9.16 in Ankara Atatürk Educational Research Hospital with diagnosed lung cancer were evaluated, retrospectively. Patients diagnosed with LC and underwent curative radiotherapy (RT) were included. Primer endpoints are the acute adverse effect and overall survey (OS).
RESULTS: : Sixty-five patients (%90,3), were male and seven (%9,7) were female. Tumor localization was 62,5% on the right side and 37.5% on the left side. 62.5% of the patients had concurrent chemotherapy. Median follow-up is 2 years. While the right lung cancer was significantly higher in patients who smoked in NSCLC than in the left lung (p0,05), this ratio was not significant in SCLC (p0,5). There is also an increase in left lung localization with increasing age in all group (p0,2). Acute side effects in NSCLC are more severe in the right lung (p0,043). In the NSCLC group, ARP developed in all 5 patients who smoked more than 50 pct and this ratio is significantly higher than in patients who smoke less than 50 pct year (p0,044). ARP in NSCLC patients is significantly more common in the right lung (p0,05) but there was no significant difference in SCLC (p 0,1). There are no statistically difference in OS between right and left lung cancer.
DISCUSSION AND CONCLUSION: LC is often seen in the right lung. Similarly, the acute pulmonary side effects are also more frequently observed on the right side in NSLC. There are no statistically difference in OS between right and left lung cancer..

Akciðer kanserinin sað yerleþimli olma eðilimi onkolojik sonuçlarý etkiler mi?

GÝRÝÞ ve AMAÇ: Akciðer kanseri (AK) en sýk görülen malignitedir ve hala kanser ölümlerinin önde gelen nedenlerinden biridir.Bu çalýþmanýn amacý, sigara kullanýmýnýn ile tümör lokalizasyonu, prognoz ve akut yan etki üzerindeki etkisini deðerlendirmektir.
YÖNTEM ve GEREÇLER: Ankara Atatürk Eðitim Araþtýrma Hastanesi'nde akciðer kanseri tanýsýyla 24.11.11-14.9.16 tarihleri arasýnda küratif torasik radyoterapi verilen 72 hasta retrospektif olarak deðerlendirildi. Primer sonlaným noktalarý, akut yan etki ve genel saðkalýmdýr (OS).
BULGULAR: Altmýþ beþ hasta (% 90,3) erkek, yedi (% 9,7) kadýndý. Tümör lokalizasyonu sað tarafta% 62,5, solda% 37.5 idi. Hastalarýn% 62.5'inde eþzamanlý kemoterapi uygulanmýþtý. Ortanca takip süresi 22 aydýr. Sað akciðer kanseri, KHDAK'de sigara içen hastalarda sol akciðere göre daha yüksek iken (p0,05), bu oran KHAK'de anlamlý deðildi (p0,5). Ayrýca tüm grupta yaþ arttýkça sol akciðer lokalizasyonunda bir artýþ vardý (p0,2). KHDAK'de akut yan etkiler sað akciðerde daha þiddetlidir (p <0,043). KHDAK grubunda, ARP, 50'den fazla sigara içen 5 hastanýn hepsinde geliþti ve bu oran, 50 yýldan az bir süre sigara içen hastalara göre anlamlý derecede yüksekti (p0.044). KHDAK hastalarýnda ARP sað akciðerde belirgin olarak daha fazladýr (p0,05), ancak KHAK'de anlamlý fark yoktu (p = 0,1). OS'de sað ve sol akciðer kanseri arasýnda bir anlamý farklýlýk yoktur.
TARTIÞMA ve SONUÇ: AK sað akciðerde daha sýk görülür. Benzer þekilde, akut pulmoner yan etkiler de KHDAK'de sað tarafta daha sýk gözlenmektedir. Genel saðkalýmda anatomik lokalizasyona göre anlamlý farklýlýk yoktur.