Otoimmün Hepatit ve Tiroid Kanseri Birlikteliði: Olgu Sunumu

Autoimmune hepatitis is a chronic Progressive liver disease. Patients vvith autoimmune hepatitis usually respond to immu-nosuppressive treatment. Treatment vvith corticosteroids and azathioprine is a milestone in achieving remission but other immu-nosuppressive drugs are also used when necessary. Development of malignancies follovving immunosuppressive treatment is well-known. Ýn addition, lymphoproliferative disorders associated vvith autoimmune diseases has been reported previously. Co-existence of autoimmune hepatitis and malignancies in other tissues, hovvever, has not been presented before. Ýn this report, we presented a case vvith autoimmune hepatitis developing thyroid papillary carcinoma 17 months after the initiation of therapy.

The Association of Autoimmune Hepatitis and Thyroid Cancer: Case Report

Otoimmün hepatit kronik, progresif bir karaciðer hastalýðýdýr. Bu hastalar genellikle immünsüpresif tedaviye yanýt verirler. Kortikosteroid ve azatioprin ile tedavi, remisyonu saðlamada köþe taþýdýr. Gerekirse diðer immünsüpresif ilaçlar da tedavide kullanýlmaktadýr. Ýmmünsüpresif tedavi sonrasý malignite geliþimi bilinmektedir. Ayrýca otoimmün hastalýklarla iliþkili lenfoproliferatif hastalýklar da önceden bildirilmiþtir. Ancak otoimmün hepatitle birlikte diðer doku malignitelerinde birliktelik daha önce sunulma-mýþtýr. Biz bu yazýda otoimmün hepatitli bir hastada tedaviye baþladýktan 17 ay sonra tiroid papiller karsinoma geliþimini sunduk.