Accompanying prostate pathologies in patients undergoing radical cystoprostatectomy due to bladder cancer

INTRODUCTION: In this study, we aimed to evaluate the accompanying prostate pathologies in patients undergoing radical cystoprostatectomy for urothelial bladder cancer.
METHODS: In the retrospective study, 197 patients who underwent radical cystectomy due to bladder tumor between 2001 and 2019 were evaluated. Those who were operated for non-urothelial bladder cancer, women, those who underwent prostate-sparing cystectomy, and those diagnosed with prostate cancer before the operation were excluded. A total of 169 male patients who underwent radical cystoprostatectomy due to urothelial bladder tumor were included in the study.
RESULTS: The mean age of the patients was 64.9 ± 8.2 (38 – 86) years. Distribution of concomitant prostate pathologies was benign prostate pathologies in 80 (47.3%), high grade prostatic intraepithelial neoplasia in 38 (22.5%) and prostate cancer in 51 (30.2%) patients. Prostate specific antigen values (3.5 ± 3.0) of patients with prostate cancer were significantly higher than those without prostate cancer (2.6 ± 4.0) (p = 0.014).
DISCUSSION AND CONCLUSION: In the management of male patients who will be operated for bladder cancer, it should be considered that prostate cancer, prostate cancer precursor lesions and prostate invasion might accompany bladder cancer. Prostate should be evaluated in detail before the operation in patients who are planned to undergo prostate-sparing cystectomy. Although the clinical importance of prostate cancer accompanying bladder cancer is controversial, the follow-up of patients with advanced Gleason score in terms of prostate cancer should not be ignored.

Mesane kanseri nedeniyle radikal sistoprostatektomi yapýlan hastalarda eþlik eden prostat patolojileri

GÝRÝÞ ve AMAÇ: Bu çalýþmada ürotelyal mesane kanseri nedeniyle radikal sistoprostatektomi yapýlan hastalarda eþlik eden prostat patolojilerini deðerlendirmeyi amaçladýk.
YÖNTEM ve GEREÇLER: Retrospektif çalýþmada, 2001 - 2019 tarihleri arasýnda mesane tümörü nedeniyle radikal sistektomi yapýlan 197 hasta deðerlendirildi. Non-ürotelyal mesane kanseri nedeniyle opere edilenler, kadýnlar, prostat korunarak sistektomi yapýlanlar ve operasyon öncesinde prostat kanseri tanýsý olan hastalar çalýþma dýþý býrakýldý. Ürotelyal mesane tümörü nedeniyle radikal sistoprostatektomi yapýlan toplam 169 erkek hasta çalýþmaya dahil edildi.
BULGULAR: Hastalarýn yaþ ortalamasý 64.9 ± 8.2 (38 – 86) yýldý. Eþlik eden prostat patolojilerinin daðýlýmý 80 (%47.3) hastada benign prostat patolojileri, 38 (%22.5) hastada yüksek dereceli prostatik intraepitelyal neoplazi ve 51 (%30.2) hastada prostat kanseri þeklindeydi. 47 (%27.81) hastada mesane kanserinin prostata invazyonu mevcuttu. Prostat kanseri saptanan hastalarýn prostat spesifik antijen deðerleri (3.5 ± 3.0) prostat kanseri olmayanlara göre (2.6 ± 4.0) anlamlý olarak yüksekti (p= 0.014).
TARTIÞMA ve SONUÇ: Mesane kanseri nedeniyle opere edilecek erkek hastalarýn yönetiminde prostat kanserinin, prostat kanseri prekürsörü lezyonlarýn ve prostata mesane kanseri invazyonun eþlik edeceði göz önünde bulundurulmalýdýr. Prostat koruyucu sistektomi planlanan hastalarda operasyon öncesi prostatýn ayrýntýlý olarak deðerlendirilmelidir. Mesane kanserine eþlik eden prostat kanserinin klinik önemi tartýþmalý olsa da, Gleason skoru yüksek ileri yaþlý hastalarýn prostat kanseri açýsýndan takibi göz ardý edilmemelidir.