Colon Cancer and Glioblastoma Multiforme Co-occurrence at an Early Age: A Case Report

The cooccurrence of colon cancer and brain tumor can be observed as Muir-Torre syndrome, Turcot syndrome, Cowden syndrome or Gardner's syndrome, in clinic. Turcot syndrome which comprises multiple adenomatous colon polyps and central nervous system (CNS) tumor is uncommon disease with mutations in DNA repair genes. We report the case of a young woman who presented with colon cancer that was developed on the ground of polyposis and after three years the patient was diagnosed glioblastoma multiforme (GBM) that couldn't be supported for Turcot Syndrome by genetic studies.

Erken Yaþta Kolon Kanseri ve Glioblastome Multiforme Birlikteliði; Olgu Sunumu

Kolon kanseri ve beyin tümörü birlikteliði klinikte karþýmýza Muir-Torre Sendromu, Turcot Sendromu, Cowden Sendromu ya da Gardner Sendromu olarak çýkabilir. Turcot Sendromu multiple adenomatöz kolon polipleri ile santral sinir sisteminin (SSS) primer tümörünün birlikte görüldüðü DNA tamir genlerinde mutasyonlarla seyreden nadir bir hastalýktýr. Biz bu olguda polipozis zemininde geliþen kolon kanseri tanýsýndan üç yýl sonra glioblastome multiforme (GBM) tanýsý alan fakat genetik çalýþmada Turcot Sendromu desteklenemeyen genç bir kadýn hastayý sunduk.