The long-term oncological results of patients under 55-year-old who underwent radical retropubic prostatectomy for localized prostate cancer

INTRODUCTION: Prostate cancer (PK) is the most common type of cancer in men and is seen especially in older ages. In this study we presented the long-term oncological results of patients who are under 55-year-old underwent radical retropubic prostatectomy (RRP).
METHODS: In this study we diagnosed with PK in 346 patients between January 2000 and June 2017 and underwent RRP in our clinic and their datas were analyzed retrospectively. Patients were divided into two groups (under (n: 64 (%18.5)) and over (n: 282 (%81.5)) 55-year-old). The results of gleason score (GS), positive surgical margin (PSM), seminal vesicle invasion (SVI), lymph node invasion (LNI, extracapsular invasion (ECI) were evaluated.
RESULTS: In our study, the mean follow-up was 80.1 ±36.1months and BCR was detected in %22.3 (n: 77) of patients during follow-up. In multivariate logistic regression analysis, BCR-related factors were; serum PSA level was>20 ng/ml, ECI, SVI, PSM and GS in RRP spesimens (p<0.05). There was no statistically significnt difference in BCR-free survival rates between age groups (under 55-year-old and older) (p: 0.9).
DISCUSSION AND CONCLUSION: In our studyi statistically significant relationship was found between BCR and presence of high PSA level, ECI, SVI, PSM and GS in parallel with the litarature; however there was no statistically significant between agre groups and BCR.

Lokalize prostat kanseri nedeniyle radikal prostatektomi uyguladýðýmýz 55 yaþ altýndaki hastalarýmýzda uzun dönem onkolojik sonuçlarýmýz

GÝRÝÞ ve AMAÇ: Prostat Kanseri (PK) erkeklerde en sýk görülen kanser türüdür ve özellikle ileri yaþlarda görülmektedir. Çalýþmamýzda 55 yaþ altýnda PK tespit ettiðimiz ve Radikal retropubik prostatektomi (RRP) uyguladýðýmýz hastalarýn uzun dönem onkolojik sonuçlarý sunuldu.
YÖNTEM ve GEREÇLER: Kliniðimizde Ocak 2000 ile Haziran 2017 tarihleri arasýnda PK tanýsý almýþ ve RRP uygulanmýþ 346 hasta çalýþmaya dahil edildi ve datalarý retrospektif olarak incelendi. Hastalar 55 yaþ altý (n: 64 (%18.5)) ve 55 yaþ üstü (n: 282 (%81.5)) olmak üzere iki gruba ayrýldý. RRP yapýlan hastalarýn gleason skor (GS), pozitif cerrahi sýnýr (PCS), seminal vezikül invazyonu (SVÝ), lenf nodu invazyonu (LNÝ), ekstrakapsüler yayýlým (EKY) sonuçlarý deðerlendirildi.
BULGULAR: Çalýþmamýzda ortalama takip süresi 80.1±36.1 ay idi ve takip esnasýnda hastalarýn % 22.3’ünde (n: 77) BCR tespit edildi. Çok deðiþkenli lojistik regresyon analizinde de BCR ile iliþkili faktörler; serum PSA düzeyinin >20 ng/ml, EKY, SVÝ, PCS ve RRP spesmeninde GS olarak tespit edildi (p<0.05). Yaþ gruplarý arasýnda (55 yaþ altý ve üstü) BCR’siz saðkalým oranlarý bakýmýndan istatistiksel olarak anlamlý fark yoktu (p: 0.9).
TARTIÞMA ve SONUÇ: Çalýþmamýzda literatüre paralel olarak yüksek PSA düzeyi, EKY, SVÝ, PCS varlýðý ve GS yüksekliði ile BCR arasýnda istatiksel olarak anlamlý iliþki bulunmuþtur; ancak yaþ gruplarý ile BCR arasýnda istatiksel olarak anlamlý iliþki bulunmamýþtýr.