Benign peripheral nerve sheath tumors of the extremities: a study of one hundred patients.

INTRODUCTION: Benign peripheral nerve sheath tumors (BPNST) are common tumors, with challenging management. The main target of surgical management of BPNSTs is excision of the tumor with preservation of neurological functions. The aim of the present study was to investigate the demographic features, clinical presentations, surgical and pathological findings, and outcomes of BPNSTs in respect of morbidity.
METHODS: A retrospective analysis of clinical and radiological findings of 100 patients with BPNSTs involving the extremities who were surgically treated at our tertiary hospital center, between 2006 and 2016.
RESULTS: In this series, evaluation was made of 100 patients comprising 52 males and 48 females with 55 schwannomas, 38 neurofibromas, 5 plexiform neurofibromas, and 2 plexiform schwannomas. The most presenting feature was painful mass. A pre-operative biopsy was performed in 20 patients with suspicion of malignancy. Of these 20 patients, 6 had post-operative motor deficits and 7 had continuous pain in the follow-up period. Recurrence was seen in 5% (5/100) patients. There were 23% patients (23/100) with BPNSTs were associated with NF type-1. The overall average follow-up was 77 months.
DISCUSSION AND CONCLUSION: BPNSTs have great clinical outcome with total excision of the tumor. BPNSTs are tumors that can be seen at any age, and generally they are presented with a palpable mass. Most of the BPNSTs are schwannomas. Orthopedic surgeons should in mind the possible nerve damage caused by a biopsy and/or surgery. Considering the balance between malignancy suspicion and possible nerve damage, biopsy should be planned carefully.

Ekstremitelerin iyi huylu periferik sinir kýlýfý tümörleri: Yüz hastanýn analizi

GÝRÝÞ ve AMAÇ: Benign periferik sinir kýlýfý tümörleri (BPSKT), sik görülen ve tedavisi zorlu tumorlerdir. BPSKT'lerin cerrahi tedavisinde ana hedef nörolojik fonksiyonlarýn korunarak tümörün eksizyonudur. Bu çalýþmanýn amacý BPSKT hastalarinin demografik özelliklerini, klinik prezentasyonlarýný, tumorun cerrahi ve patolojik bulgularýný ve morbidite açýsýndan sonuçlarýný araþtýrmaktýr.
YÖNTEM ve GEREÇLER: 2006 ve 2016 yýllarý arasýnda üçüncü basamak hastanemizde cerrahi olarak tedavi edilen ekstremite yerleþimli BPSKT'li 100 hastanýn klinik ve radyolojik bulgularýnýn retrospektif bir analizi yapýldý.
BULGULAR: Bu seride 55 schwannom, 38 nörofibrom, 5 pleksiform nörofibrom ve 2 pleksiform schwannom olmak uzere 52’si erkek 48’i kadýn toplam 100 hastanýn deðerlendirilmesi yapýldý. En sik klinik prezentasyon aðrýlý kitleydi. Malignite þüphesi olan 20 hastaya ameliyat öncesi biyopsi yapýldý. Bu 20 hastanýn poatoperatif takiplerinde 6'sýnda motor defisit, 7'sinde sürekli aðrý saptandi. %5 (5/100) hastada nüks görüldü. BPSKT 'lerin %23'ü (23/100) NF tip-1 ile iliþkiliydi. Ortalama takip süresi 77 aydý.
TARTIÞMA ve SONUÇ: BPSKT’ler tümörün tamamen eksizyonu ile mükemmel klinik sonuçlara sahiptir. BPSKT’leri her yaþta görülebilirler ve genellikle ele gelen kitle þikayetiyle baþvururlar. Çoðu BPSKT’lerini schwannomalar oluþturmaktadýr. Ortopedistler bir biyopsi ve / veya cerrahi iþlemden kaynaklanan olasý sinir hasarýný göz önünde bulundurmalýdýr. Malignite þüphesi ile olasý sinir hasarý arasýndaki denge göz önüne alýndýðýnda, biyopsi dikkatle planlanmalýdýr.