The Prognostic Factors in Endometrial Cancers Treated with Radiotherapy: Retrospective Analysis

INTRODUCTION: Endometrial cancer is mostly diagnosed in the early stages and has a good prognosis. Surgery has main role in the treatment of patients with endometrial cancer and adjuvant radiotherapy (RT) is administered in certain risk groups. In this retrospective study, we analyzed the factors affecting the prognosis of patients with endometrial cancer who underwent RT.
METHODS: A total of 181 patients who were diagnosed with endometrial cancer were included in the study. Based on the prognostic factors, risk groups were recorded as low, intermediate, high-intermediate, high risk, and advanced/metastatic. Patients’ overall survival (OS) was calculated using Kaplan– Meier method.
RESULTS: Median age was 60 years (28–82). The number of patients who received adjuvant RT alone, RT and chemotherapy, and chemotherapy alone were 77 (42.5%), 65 (36%), and 39 (21.5%), respectively. Median OS was 12.4 (range, 0.1-21) years. Except for the advanced/metastatic risk group, OS was better in all the other risk groups who received RT alone (p<0.001).
DISCUSSION AND CONCLUSION: Risk groups (based on prognostic risk factors), p53, and treatment applied (RT alone) are the significant prognostic indicators for patients received adjuvant therapy in endometrial cancer. Adding adjuvant chemotherapy to RT adversely affects the prognosis.

Radyoterapi Uygulanan Endometriyal Kanserlerinde Prognostik Faktörler: Retrospektif Analiz

GÝRÝÞ ve AMAÇ: Endometriyal kanser çoðunlukla erken evrelerde teþhis edilir ve iyi bir prognoza sahiptir. Endometriyal kanserli hastalarýn tedavisinde cerrahi tedavi temeldir ve belirli risk gruplarýnda adjuvan radyoterapi (RT) uygulanmaktadýr. Bu retrospektif çalýþmada, RT uygulanan endometriyal kanserli hastalada prognozu etkileyen faktörler inceledi.
YÖNTEM ve GEREÇLER: Çalýþmaya endometriyal kanser tanýsý almýþ toplam 181 hasta dahil edildi. Prognostik faktörlere göre risk gruplarý düþük, orta, yüksek-orta, yüksek riskli ve ileri/metastatik olarak kaydedildi. Hastalarýn genel saðkalýmý (GS), Kaplan-Meier yöntemi kullanýlarak hesaplandý.
BULGULAR: Ortanca yaþ 60'tý (28-82). Tek baþýna adjuvan RT, RT ve kemoterapi ve tek baþýna kemoterapi alan hasta sayýsý sýrasýyla 77 (%42,5), 65 (%36) ve 39 (%21,5) idi. Ortanca GS 12.4 (0.1-21) yýldý. Ýleri/metastatik risk grubu dýþýnda diðer tüm risk gruplarýnda, tek baþýna RT alan hastalarda GS daha iyi bulundu (p<0.001).
TARTIÞMA ve SONUÇ: Endometriyal kanserli hastalarda adjuvan tedavi alanlarda; risk gruplarý (prognostik risk faktörlerine göre), p53 ve uygulanan tedavi (yalnýz RT) önemli prognostik göstergelerdir. RT'ye adjuvan kemoterapi eklenmesi prognozu olumsuz etkilemektedir.