Relation between clinical, histopathological properties and microvessel density assessed by CD105 and CD31 in prostate carcinoma

INTRODUCTION: We designed this study in order to investigate the relation between histopathological and clinical properties in prostatic carcinoma patients and microvessel density (MVD) of tumoral and peritumoral tissue, assessed by CD105 and CD31 expression.
METHODS: A total of 100 radical prostatectomy samples, have been evaluated retrospectively with clinical and histopathological findings. Immunohistochemical markers of CD105 and CD31 were applied to the tumoral tissue and surroundings of tumor. Relation between tumoral and peritumoral CD105, CD31 and clinical or histopathological findings was evaluated.
RESULTS: CD105 and CD31 together with MVD have been found more significant in the tumoral tissue than the periphery (p<0,001). CD105 expression in the peritumoral tissue was significantly lower than the CD31 expression. A significant correlation has been found between CD105 MVD in the tumoral tissue and the preoperative serum total PSA levels and tumor volume (r=0.259, p=0.009, r=0.198, p=0.049, respectively). Tumoral CD105 expression was significantly higher in cases with perineural invasion, lymph node metastasis and local invasion (p=0.003, p=0.009, p=0.044). CD31 expression was significantly correlated with pathological stage (r=0.228, p= 0.022, p=0,034, respectively). Cases with seminal vesicle invasion and extracapsular extension had with significantly higher CD31 MVD. No significant correlation was found between peritumoral tissue MVD and clinical or histopathological findings.
DISCUSSION AND CONCLUSION: Finding of association between CD105 and CD31 in the tumoral tissue and prognostic clinical findings, supports the importance of angiogenesis in tumoral progression. This may reveal new treatment modalities for research involving anti-angiogenic agents.

Prostat karsinomunda CD105 ve CD31 ile araþtýrýlan mikrovasküler yoðunluðun klinik ve histopatolojik bulgularla iliþkisi

GÝRÝÞ ve AMAÇ: Bu çalýþmayý, prostat kanserinde, tümör dokusunda ve tümör çevresinde CD105 ve CD31 ile araþtýrýlan mikrovasküler yoðunluðun (MVY) histopatolojik ve klinik bulgularla iliþkisini araþtýrmak amacýyla planladýk.
YÖNTEM ve GEREÇLER: Çalýþmamýzda, Patoloji Bölümünde incelenmiþ 100 radikal prostatektomi materyali klinik ve histopatolojik bulgularý açýsýndan retrospektif olarak deðerlendirildi. Her bir materyaldeki tümör dokusuna ve tümör çevresine CD105 ve CD31 immünohistokimyasal belirteçleri uygulandý. Tümoral ve peritümöral CD105 ve CD31 ile MVY ekspresyonu, klinik ve histopatolojik bulgularla karþýlaþtýrýldý.
BULGULAR: Tümör dokusunda CD105 ve CD31 ile MVY, tümör çevresindekinden anlamlý olarak fazla bulundu (p<0.001). Tümör çevresindeki CD105 ile boyanan damar sayýsý, tümör çevresindeki CD31 ile boyanan damar sayýsýndan anlamlý derecede düþük bulundu (p<0.001). Tümör dokusundaki CD105 MVY ile preoperatif serum total PSA düzeyi, tümör hacmi, perinöral invazyon, lenf düðümü metastazý ve lokal invazyon arasýnda anlamlý iliþki bulundu (sýrasýyla r=0,338 ve p<0,001, p= 0,003, p= 0,009, p= 0,044). Tümör dokusundaki CD31 MVY ekspresyonu ile patolojik evre, cerrahi sýnýrda tümör bulunmasý ve veziküloseminalis invazyonu arasýnda anlamlý iliþki bulundu (sýrasýyla r=0,228 ve p= 0,022, p=0,034).Tümör çevresindeki CD105 ve CD31 MVY ekspresyonu ile klinik ve histopatolojik bulgular arasýnda anlamlý iliþki görülmedi (p > 0,05).
TARTIÞMA ve SONUÇ: Tümör dokusundaki CD105 ve CD31 MVY’nun, prognostik açýdan önemli klinik bulgularla iliþkili olmasý, tümör pogresyonunda anjiogenezin önemini vurgulamaktadýr. Bu bulgu anti-anjiojenik ajanlarý içeren yeni tedavi modalitelerinin geliþmesini saðlayacaktýr.