Abstract

INTRODUCTION

In our study, we aimed to evaluate the factors that affect the prognosis of patients with transformed lymphoma who are followed up in our clinic.

METHODS

Forty-five patients with transformed lymphoma who were eligible for our study were retrospectively analyzed. The preparations of the patients were confirmed by experienced pathologists with second look.

RESULTS

The majority of the primary diagnosis of the patients was follicular lymphoma. The most common type of transformed lymphoma was diffuse large B-cell lymphoma (DLBCL). The time to transformation was measured as 31 months (2-312). The number of patients who responded to the first rescue treatment after transformation was 32 (71%), and the number of refractory patients was 9 (20%). Median survival in transformed patients was 4.5 months (1-102).

DISCUSSION AND CONCLUSION

The time to transformation was measured as 31 months. The fact that this period is shorter compared to some studies in the literature may be due to close follow-up of the patients and diagnosis in a short time. In addition, heterogeneity in the diagnosis type of primary diseases and the treatments received are another reason that may explain the difference in transformation times between studies. More studies are needed for more accurate prognostic assessment.