The Predictive Value of FDG-PET / CT in Assessing Bone Marrow Involvement in Hodgkin Lymphoma Patients; A Single Center ExperiencIe
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Original Article
P: 352-357
2021

The Predictive Value of FDG-PET / CT in Assessing Bone Marrow Involvement in Hodgkin Lymphoma Patients; A Single Center ExperiencIe

Acta Haematol Oncol Turc 2021;54(3):352-357
1. University Of Health Scineces Ankara Dışkapı Yıldırım Beyazıt Training And Research Hospital, Hematology Department, Ankara, Türkiye
2. Ministry Of Health Hitit University Erol Olçok Training And Research Hospital, Hematology Department, Çorum, Türkiye
3.
No information available.
No information available
Received Date: 2021-02-14T16:10:27
Accepted Date: 2021-12-01T07:10:59
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Abstract

INTRODUCTION

This study was conducted to determine the predictive value of positron emission tomography (PET/CT) used in staging Hodgkin Lymphoma (HL) at the time of diagnosis in determining bone marrow (BM) involvement.

METHODS

The patients diagnosed with Hodgkin lymphoma in our hematology department between 2009-2019 were analyzed retrospectively. The study included a total of 46 patients who underwent both BM biopsy and PET / CT for staging at the time of diagnosis.

RESULTS

The mean age of the 46 patients was 40.0 years [19.0-80.0]. BM involvement was determined in 3 patients from BM biopsy and in 14 patients from PET / CT performed at the time of diagnosis. When PET / CT results were analyzed according to BM biopsy results, it was found that the sensitivity was 100% (3/3) and the specificity was 74.4% (32/43).

DISCUSSION AND CONCLUSION

The sensitivity of PET / CT is very high in detecting BM involvement in HL patients, and is a non-invasive test. However, in doubtful cases it may be more appropriate to perform a BM biopsy, even though it is invasive, as PET/CT may cause false positive patient staging due to its low specificity.

Keywords:
Hodgkin Lymphoma
bone marrow involvement
PET/CT