Abstract

INTRODUCTION

In this study we aimed to evaluate the follow up and treatment modalities along with the results of the patients with pancreatic pseudopapillary tumors (SPT)

METHODS

We evaluated the clinical and pathological parameters, treatments and long-term follow-up results of 12 patients diagnosed with SPT between 2005 and 2016 in our clinic.

RESULTS

Two thirds of patients were female and median age was 39.5 years (range 19-71). Pancreatic tail (%53.8) was the most common site for tumor localization. Distal pancreatectomy (n=7), Whipple surgery (n=4) and total pancreatectomy (n=1) were the surgical procedures. Mean tumor diameter was 8.4 cm (range= 4-15 cm). We identified perineural invasion (PNI) in 3 patients and lymphovascular invasion (LVI) in 2 patients. Three patients received adjuvant radiotherapy following 6 cycles of adjuvant chemotherapy since they were considered as malign SPT. Two of them received 6 cycles of gemcitabine whereas the other one was 6 cycles of capecitabine as adjuvant chemotherapy. Median overall and disease-free survival were not reached. Only 3 (25%) patients relapsed at a median follow-up of 25.1 months (range= 1.9-84.1).

DISCUSSION AND CONCLUSION

We consider that nodal involvement, LVI, PNI, advanced age and male gender might be poor prognostic factors in SPT. Ajuvant chemotherapy and/or radiotherapy might be considered for these patients. However, we need prospective clinical trials to determine poor risk factors and the treatment modalities for the patients with poor prognistic factors.