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Systemic Immune-Inflammation Index and Hodgkin Lymphoma: an Underexplored Relationship
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Original Article
VOLUME: 56 ISSUE: 3
P: 259-271
2023

Systemic Immune-Inflammation Index and Hodgkin Lymphoma: an Underexplored Relationship

Acta Haematol Oncol Turc 2023;56(3):259-271
DOI: 10.5505/aot.2023.62582
Emine Gültürk 1
Korhan Kapucu 1
Eyyup Akkaya 1
Deniz Yılmaz 2
Fehmi Hindilerden 1
1. Department of Hematology, Bakirkoy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey
2. Department of Internal Medicine, Bakirkoy Dr Sadi Konuk Training and Research Hospital, Istanbul, Turkey
3.
No information available.
No information available
Received Date: 2023-05-09T14:16:24
Accepted Date: 2023-12-04T07:27:54
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Abstract

INTRODUCTION

Tumor-associated inflammation is an important feature of tumor development and progression. We aimed to investigate whether the clinicopathological and prognostic characteristics of patients with classical Hodgkin lymphoma (cHL) were associated with systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR).

METHODS

This was a retrospective cohort study conducted between January 2012 and December 2021. A total of 77 patients with newly diagnosed cHL were included in the study.

RESULTS

The median age of the patients was 37 (24-49) years. Patients with stage IV disease (p=0.036), B symptoms (p=0.005), and extranodal involvement (p=0.012) had significantly higher NLR. Female patients (p=0.005), those with B symptoms (p=0.014) and subjects with extranodal involvement (p=0.011) had significantly higher PLR. Also, the SII of patients with B symptoms was significantly higher compared to those without (p=0.009). There were significant but weak correlations between international prognostic score-7 and SII (r=0.271, p=0.017), PLR (r=0.294, p=0.010) and NLR (r=0.378, p=0.001).

DISCUSSION AND CONCLUSION

SII was associated with B symptoms, but was not prognostic for cHL. PLR and NLR were also unassociated with prognosis in patients with cHL. However, considering the exceedingly limited data on this topic, further studies to assess inflammation indices are necessary.