ABSTRACT

Aim: This study aimed to investigate the impact of post-treatment positron emission tomography-computed tomography (PET/CT) findings on predicting disease prognosis in patients with T-cell lymphoma.

Methods: Patients diagnosed with T-cell lymphoma and admitted to the Medical Oncology Clinic of Gazi University Medical Faculty Hospital between 2004 and 2014 were retrospectively evaluated. The study included 24 patients who underwent PET/CT for staging. The correlation between post-treatment PET/CT findings and progression-free survival (PFS) and overall survival (OS) was analyzed.

Results: The 1- and 2-year PFS rates were 78.6% and 50% in the PET-negative group and 40% and 0% in the PET-positive group (p=0.007). No statistically significant difference was found between the two groups regarding 1- and 2-year OS rates (p=0.113). As a result of multivariate cox regression analyses, only age was found to be effective for OS and PFS, and the risk of progression and death increased with older age.

Conclusion: Post-treatment PET/CT findings were not independent predictors of PFS and OS in T-cell lymphomas. However, the small sample size and retrospective design of the study warrant further research with larger patient cohorts.